CERENOVUS Neurothrombectomy Devices Registry

Last updated: May 29, 2025
Sponsor: Cerenovus, Part of DePuy Synthes Products, Inc.
Overall Status: Completed

Phase

N/A

Condition

Stroke

Cerebral Ischemia

Treatment

CEREGLIDE 71 Intermediate Catheter

EmboTrap® Revascularization Device

CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter

Clinical Study ID

NCT03685578
CNV_2017_02
  • Ages > 18
  • All Genders

Study Summary

A post-market registry evaluating the EmboTrap® Revascularization Device, CERENOVUS Large Bore Catheter/ EMBOVAC™ Aspiration Catheter, and CEREGLIDE 71 Intermediate Catheter in acute ischemic stroke patients with confirmed intracranial vessel occlusion.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age ≥ 18

  2. The participant or the participant's legally authorized representative has signedand dated an Informed Consent Form. In the event that local regulations allow foralternative approaches of consent, these must be fulfilled as approved by thesponsor and site's ethics committee/regulatory authority (if applicable)

  3. Participants experiencing acute ischemic stroke with angiographic confirmation ofintracranial vessel occlusion

  4. A clinical decision has been made to use a CERENOVUS neurothrombectomy device (EmboTrap® Revascularization Device, Large Bore Catheter/ EMBOVAC AspirationCatheter, or CEREGLIDE 71 Intermediate Catheter) independently and prior toenrollment in the research study

  5. A CERENOVUS neurothrombectomy device is the first attempted primary device/techniquefor mechanical thrombectomy for the intracranial occlusion in the participant. Thefollowing primary devices/techniques are eligible for this study: a) EmboTrap®Revascularization Device alone b) EmboTrap® Revascularization Device + co-aspirationwith the Large Bore Catheter/EMBOVAC Aspiration Catheter or CEREGLIDE 71Intermediate Catheter c) EmboTrap® Revascularization Device + co-aspiration with anyother aspiration catheter d) Large Bore Catheter/EMBOVAC Aspiration Catheter alone (that is, direct aspiration with no stent retriever in the first attemptedtechnique) e) CEREGLIDE 71 Intermediate Catheter alone (that is, direct aspirationwith no stent retriever in the first attempted technique)

Exclusion

Exclusion Criteria:

  1. Currently participating in an investigational (drug, device, etc) clinical trialthat may confound study endpoints. Patients in observational, natural history,and/or epidemiological studies not involving intervention are eligible

  2. Confirmation of positive pregnancy test according to site specific standard of care (example, test, verbal communication)

  3. Use of multiple stent retrievers on the first pass

Study Design

Total Participants: 2000
Treatment Group(s): 3
Primary Treatment: CEREGLIDE 71 Intermediate Catheter
Phase:
Study Start date:
September 28, 2018
Estimated Completion Date:
February 20, 2025

Study Description

The objective of this study are to separately assess the effectiveness of the CERENOVUS neurothrombectomy devices (EmboTrap® Revascularization Device, Large Bore Catheter/EMBOVAC Aspiration Catheter, and CEREGLIDE 71 Intermediate Catheter) in a real-world setting, as well as to explore correlations between patient comorbidities, clot characteristics, revascularization rates, and clinical outcomes.

Connect with a study center

  • Az Groeninge

    Kortrijk, 8500
    Belgium

    Site Not Available

  • Hopital Roger Salengro - CHU Lille

    Lille, 59037
    France

    Site Not Available

  • Klinikum Dortmund gGmbH

    Dortmund, 44137
    Germany

    Site Not Available

  • Universitaetsklinikum Hamburg Eppendorf

    Hamburg, 20246
    Germany

    Site Not Available

  • Universitaetsmedizin Mainz

    Mainz, 55101
    Germany

    Site Not Available

  • Radprax MVZ Nordrhein GmbH

    Solingen, 42651
    Germany

    Site Not Available

  • Hadassah Medical Center

    Jerusalem, 91120
    Israel

    Site Not Available

  • Kantonsspital Aarau

    Aarau, 5001
    Switzerland

    Site Not Available

  • Centre Hospitalier Universitaire Vaudois (CHUV)

    Lausanne, CH-1011
    Switzerland

    Site Not Available

  • Charing Cross Hospital

    London, W6 8RF
    United Kingdom

    Site Not Available

  • The University of Alabama at Birmingham

    Birmingham, Alabama 35294
    United States

    Site Not Available

  • Banner Desert Medical Center

    Mesa, Arizona 85202
    United States

    Site Not Available

  • Barrow Neurological Institute at St. Joseph's Hospital

    Phoenix, Arizona 85013
    United States

    Site Not Available

  • Vascular Neurology of Southern California: Dr. M. Asif Taqi

    Thousand Oaks, California 91360
    United States

    Site Not Available

  • Memorial Regional Hospital

    Hollywood, Florida 33021
    United States

    Site Not Available

  • Baptist Medical Center

    Jacksonville, Florida 32207
    United States

    Site Not Available

  • Lyerly Neurosurgery Baptist Health

    Jacksonville, Florida 32207
    United States

    Site Not Available

  • University of Miami- Jackson Memorial Hospital

    Miami, Florida 33133
    United States

    Site Not Available

  • Advent Health Orlando

    Orlando, Florida 32803
    United States

    Site Not Available

  • Emory School of Medicine at Grady Memorial Hospital

    Atlanta, Georgia 30303
    United States

    Site Not Available

  • WellStar Health System

    Marietta, Georgia 30060
    United States

    Site Not Available

  • Norton Neurology Institute

    Elizabethtown, Kentucky 42701
    United States

    Site Not Available

  • Norton Healthcare

    Louisville, Kentucky 40241
    United States

    Site Not Available

  • University of Massachusetts

    Worcester, Massachusetts 30303
    United States

    Site Not Available

  • Vanderbilt University Medical Center

    Nashville, Missouri 37232
    United States

    Site Not Available

  • Washington University in St. Louis

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • Jacobs Institute/UB Neurosurgery, Inc.

    Buffalo, New York 14203
    United States

    Site Not Available

  • Icahn School of Medicine at Mount Sinai

    New York, New York 10029
    United States

    Site Not Available

  • Cleveland Clinic

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Ohio Health

    Columbus, Ohio 43214
    United States

    Site Not Available

  • Mercy Health St Vincent Medical Center

    Toledo, Ohio 43608
    United States

    Site Not Available

  • Oregon Health & Science University

    Portland, Oregon 97201
    United States

    Site Not Available

  • Geisinger

    Danville, Pennsylvania 17822
    United States

    Site Not Available

  • Geisinger Clinic

    Danville, Pennsylvania 17822
    United States

    Site Not Available

  • Thomas Jefferson University

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

  • TNVI

    Knoxville, Tennessee 37902
    United States

    Site Not Available

  • University of Tennessee Medical Center

    Knoxville, Tennessee 37920
    United States

    Site Not Available

  • Semmes Murphey Foundation

    Memphis, Tennessee 38120
    United States

    Site Not Available

  • University of Texas Houston

    Houston, Texas 77030
    United States

    Site Not Available

  • Texas Stroke Institute

    Plano, Texas 75075
    United States

    Site Not Available

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