Study of Cabozantinib as Monotherapy or in Combination With Nivolumab in Patients With Advanced or Metastatic Renal Cell Carcinoma Under Real-life Clinical Setting in 1st Line Treatment.

Last updated: March 31, 2025
Sponsor: Ipsen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Carcinoma

Treatment

N/A

Clinical Study ID

NCT03647878
A-DE-60000-009
  • Ages > 18
  • All Genders

Study Summary

The purpose of the protocol, is to describe the use of cabozantinib tablets as monotherapy or in combination with nivolumab including the number of dose reductions, dose interruptions and terminations due to (serious) adverse events in subjects with advanced or metastatic renal cell carcinoma (mRCC) treated in real-life clinical setting in 1st line treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Males or females aged 18 years and older with capacity to consent.

  • Subjects receiving cabozantinib as monotherapy or in combination with nivolumab as afirst line treatment for advanced or metastatic renal cell carcinoma

  • Subjects with the intention to be treated with cabozantinib tablets as monotherapyor in combination with nivolumab according to the current local Summary of ProductCharacteristics (SmPC); decision has to be taken before entry in the study.

  • Signed written informed consent

Exclusion

Exclusion Criteria:

  • Participation in an interventional study at the same time and/or within 3 monthsbefore baseline.

  • Previous participation in this study

Study Design

Total Participants: 210
Study Start date:
September 24, 2018
Estimated Completion Date:
September 30, 2027

Connect with a study center

  • Landeskrankenhaus Hochsteiermark

    Leoben, A-8700
    Austria

    Active - Recruiting

  • Kepler Universitätsklinikum GmbH

    Linz, 4021
    Austria

    Active - Recruiting

  • Ordensklinikum Linz GmbH

    Linz, 4020
    Austria

    Site Not Available

  • Uniklinikum Salzburg

    Salzburg, A-5020
    Austria

    Terminated

  • Salzkammergutklinikum Vöcklabruck

    Vöcklabruck, A-4840
    Austria

    Site Not Available

  • Klinikum Wels-Grieskirchen GmbH

    Wels, 4600
    Austria

    Active - Recruiting

  • Universitätsklinikum Aachen

    Aachen,
    Germany

    Active - Recruiting

  • Urologisches Zentrum Euregio

    Aachen,
    Germany

    Site Not Available

  • Onkologie aschaffenburg

    Aschaffenburg, 63739
    Germany

    Active - Recruiting

  • Universitätsklinikum Augsburg A.ö.R

    Augsburg, 86156
    Germany

    Active - Recruiting

  • MVZ Taunus GmbH

    Bad Homburg,
    Germany

    Site Not Available

  • Hämatologisch-Onkologische Schwerpunktpraxis

    Bad Liebenwerda,
    Germany

    Active - Recruiting

  • Urologische Praxis Bad Schlema

    Bad Schlema,
    Germany

    Active - Recruiting

  • Klinikum am Bruderwald Medizinische Klinik V

    Bamberg, 96049
    Germany

    Active - Recruiting

  • GFO Kliniken Rhein-Berg

    Bergisch Gladbach,
    Germany

    Active - Recruiting

  • Onkologie am Segelfliegerdamm

    Berlin, 12487
    Germany

    Site Not Available

  • Praxis Urologie Köpenick

    Berlin,
    Germany

    Site Not Available

  • Praxis am Volkspark

    Berlin,
    Germany

    Site Not Available

  • Praxis für Urologie

    Berlin, 12099
    Germany

    Site Not Available

  • Urologische Praxis Berlin

    Berlin,
    Germany

    Site Not Available

  • Vivantes Klinikum am Urban

    Berlin,
    Germany

    Active - Recruiting

  • Zentrum für urologische Onkologie, Palliativmedizin und allgemeine Urologie

    Berlin,
    Germany

    Site Not Available

  • überörtl. Praxis für Urologie & Onkologie

    Berlin, 13055
    Germany

    Site Not Available

  • Urologische Arztpraxis

    Bernburg,
    Germany

    Site Not Available

  • Franziskus Hospital Bielefeld

    Bielefeld, 33615
    Germany

    Site Not Available

  • Centrum für Operative Urologie

    Bremen, 28277
    Germany

    Terminated

  • Klinikum Bremen Mitte

    Bremen,
    Germany

    Active - Recruiting

  • Edia.med MVZ

    Chemnitz, 09130
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis für Urologie Cottbus

    Cottbus,
    Germany

    Active - Recruiting

  • Onkologisches Zentrum Donauwörth

    Donauwörth, 86609
    Germany

    Site Not Available

  • Gemeinschaftspraxis Hämatologie-Onkologie, Dresden

    Dresden,
    Germany

    Site Not Available

  • Onkozentrum Dresden/Freiberg

    Dresden, 01127
    Germany

    Active - Recruiting

  • Urologische Gemeinschaftspraxis

    Dresden, 01307
    Germany

    Active - Recruiting

  • Fachzentrum für Urologie Eggenfelden

    Eggenfelden,
    Germany

    Site Not Available

  • St. Georg Klinikum

    Eisenach, 99817
    Germany

    Active - Recruiting

  • Uniklinikum Erlangen

    Erlangen,
    Germany

    Active - Recruiting

  • Markuskrankenhaus

    Frankfurt am main,
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis

    Garbsen, 30823
    Germany

    Active - Recruiting

  • Universitätsklinikum Gießen und Marburg GmbH

    Gießen,
    Germany

    Active - Recruiting

  • Universitätsmedizin Göttingen

    Göttingen, 37075
    Germany

    Active - Recruiting

  • Krankenhaus Martha-Maria Halle-Dölau

    Halle,
    Germany

    Active - Recruiting

  • Asklepios Klinik Altona

    Hamburg,
    Germany

    Active - Recruiting

  • Evangelisches Krankenhaus Hamm gGmbH

    Hamm, 59063
    Germany

    Site Not Available

  • Immunologisch onkologisches MVZ

    Hannover, 30449
    Germany

    Active - Recruiting

  • Onkologisches Studienzentrum am Raschplatz

    Hannover, 30161
    Germany

    Active - Recruiting

  • Kreiskliniken Herford

    Herford,
    Germany

    Active - Recruiting

  • Uniklinik Jena

    Jena,
    Germany

    Active - Recruiting

  • Onkologische Schwerpunktpraxis

    Kronach,
    Germany

    Active - Recruiting

  • Praxis für Hämatologie, Onkologie und Gerinnung

    Kronach, 96317
    Germany

    Active - Recruiting

  • Studienzentrum UnterEms

    Leer,
    Germany

    Active - Recruiting

  • Urologische Arztpraxis

    Leipzig,
    Germany

    Active - Recruiting

  • Urologische Praxis

    Luckenwalde,
    Germany

    Active - Recruiting

  • Urologische Arztpraxis

    Lutherstadt Eisleben, 06295
    Germany

    Site Not Available

  • Universitätsklinikum Magdeburg

    Magdeburg, 39120
    Germany

    Active - Recruiting

  • Uniklinik Marburg

    Marburg,
    Germany

    Active - Recruiting

  • Praxis für Urologie, Andrologie, Onkologie und medikamentöse Tumortherapie

    Markkleeberg, 04416
    Germany

    Active - Recruiting

  • Urologische Gemeischaftspraxis Hochsauerland

    Meschede, 59872
    Germany

    Site Not Available

  • Onkologische Praxis Moers

    Moers, 47441
    Germany

    Site Not Available

  • Kliniken Maria Hilf GmbH

    Mönchengladbach, 41063
    Germany

    Site Not Available

  • Facharztpraxis für Hämatologie und Internistische Onkologie

    München, 80331
    Germany

    Site Not Available

  • LMU Urologische Klinik und Poliklinik

    München,
    Germany

    Active - Recruiting

  • Universitätsklinikum Münster

    Münster, 48149
    Germany

    Active - Recruiting

  • Praxis Naunhof

    Naunhof,
    Germany

    Active - Recruiting

  • Urologische Gemeinschaftspraxis

    Neunkirchen, 66538
    Germany

    Site Not Available

  • Praxis für Hämatologie und Internistische Onkologie

    Neustadt Am Rübenberge, 31535
    Germany

    Active - Recruiting

  • Klinikum Nürnberg

    Nürnberg, 90419
    Germany

    Active - Recruiting

  • MVZ Urologie gGmbH

    Nürnberg,
    Germany

    Active - Recruiting

  • Sana Klinikum Offenbach GmbH

    Offenbach,
    Germany

    Active - Recruiting

  • MVZ Kreis Olpe

    Olpe, 57462
    Germany

    Active - Recruiting

  • Klinikum Osnabrück GmbH

    Osnabrück,
    Germany

    Active - Recruiting

  • Brüderkrankenhaus St. Josef Paderborn

    Paderborn, 33098
    Germany

    Active - Recruiting

  • Urologische Praxis

    Parchim, 19370
    Germany

    Site Not Available

  • Urologie

    Potsdam,
    Germany

    Site Not Available

  • Krankenhaus Barmherzige Brüder Regensburg

    Regensburg,
    Germany

    Active - Recruiting

  • Elblandklinikum Riesa

    Riesa, 01589
    Germany

    Site Not Available

  • Wissenschaftskontor Nord GmbH &Co KG

    Rostock, 18107
    Germany

    Site Not Available

  • MVZ MP Saaletal

    Saalfeld/Saale, 07318
    Germany

    Site Not Available

  • Zentrum für Ambulante Onkologie

    Schorndorf, 73614
    Germany

    Active - Recruiting

  • Klinikum Sindelfingen-Böblingen

    Sindelfingen, 71065
    Germany

    Active - Recruiting

  • Klinikum Solingen

    Solingen,
    Germany

    Active - Recruiting

  • Krankenhaus Torgau J. Kentmann gGmbH

    Torgau,
    Germany

    Site Not Available

  • Krankenhaus der Barmherzigen Brüder Trier

    Trier, 54292
    Germany

    Active - Recruiting

  • Medizinische Studiengesellschaft Nord-West GmbH

    Westerstede, 26655
    Germany

    Active - Recruiting

  • Praxisgemeinschaft für Onkologie und Urologie

    Wilhelmshaven, 26389
    Germany

    Active - Recruiting

  • GIM - Gemeinschaftspraxis Innere Medizin

    Witten, 58455
    Germany

    Active - Recruiting

  • Onkologische Schwerpunktpraxis Wolfsburg

    Wolfsburg, 38440
    Germany

    Site Not Available

  • Praxis Urologie Köpenick

    Zwickau,
    Germany

    Site Not Available

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