The Application of 3T MRI in Esophageal Cancer

Last updated: March 31, 2020
Sponsor: Henan Cancer Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Digestive System Neoplasms

Esophageal Disorders

Cancer

Treatment

N/A

Clinical Study ID

NCT03635619
FSK001
  • Ages 18-75
  • All Genders

Study Summary

It is very significant that assessing TN staging in esophageal cancer patients before surgery, furthermore, determining the optimize surgical strategy, predict the the efficacy of radiotherapy for patients who were not chosen to be surgeried, and define the range of lymph node for radiotherapy. It has been reported that the application of MRI in metastasis of lymph node of other cancer, but not in metastasis lymph node with esophageal cancer. Only a few studies focused on T staging using conventional MRI in esophageal cancer, however, relatively new sequences in the chest deserve widely used. To develop a pre-treatment evaluation methods for TN staging in patient with esophageal cancer by utilization of the new imaging methods (T2-TSE-BLADE, T2 maps, StarVIBE). By analysising the relationship between TN staging and imaging features to find the imaging characteristics for TN staging, and to find the indicators of magnetic resonance imaging new technology and reference values for facilitate pre-treatment diagnosis of lymphnode metastasis, optimize surgical strategy, predict the the efficacy of adjunctive therapy, and OS and define the range of lymph node for radiotherapy, as making personal treatment planning for esophageal cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Consecutive patients with preoperative pathologically con-firmed EC by endoscopy andpreoperative imaging data (esophagography\CT\EUS\MRI) were included.

  2. No contraindications for MRI examination.

  3. The patients participate in this study with informed consent.

Exclusion

Exclusion Criteria:

  1. The patients couldn't performed MR scanning or artefacts affect the evaluation.

  2. ThePatients are extremely anxious and uncooperative about surgery or neoadjuvanttherapy.

  3. PatientsThe patients refuse to participate in the project.

Study Design

Total Participants: 400
Study Start date:
September 02, 2018
Estimated Completion Date:
December 30, 2023

Study Description

To explore the value of 3 T MRI using multiple sequences, including T2-TSE-BLADE, T2 maps and StarVIBE, in evaluating the preoperative TN staging and prediction of response to neoadjuvant therapy and OS in patients with esophageal cancer.

Patients with endoscopically biopsy-proven EC were prospectively enrolled for imaging on a 3 T scanner. The MRI protocol included T2-TSE-BLADE, T2 maps and StarVIBE sequences, and so on. Patients received treatment according to NCCN guideline. Readers assigned a TN stage on MRI, and post-operative pathologic confirmation was considered the gold standard. Inter-reader agreement, the diagnostic accuracy of TN staging on MRI were analyzed and compared to post-operative pathologic TN staging. MRI features were analyzed to find the correlation between pretreatment MRI features and response or OS. The study will includ 400 patients. Inter-reader agreements of TN staging were analyzed excellent for MRI. Diagnostic accuracy of MRI will be calculated.

Connect with a study center

  • Henan Cancer Hospital

    Zhengzhou,
    China

    Active - Recruiting

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