Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial

Inclusion Criteria:-

• Informed consent obtained before any study-related activities. Study-relatedactivities are any procedures that are carried out as part of the study.

• Male or female, age 18 years or older at the time of signing informed consent.

• Type 2 diabetes mellitus diagnosis.

• Treatment with either 1 or 2 oral antidiabetic medications.

• Current member of a commercial or Medicare health plan with pharmacy benefits.

• Recorded HbAlc value within the last 90 days prior to randomization.

• Further intensification with an additional antidiabetic oral or injectablemedication is indicated to achieve glycemic target at the discretion of the studyphysician according to approved labelling.

Exclusion Criteria:

• Previous randomization in this study

• Treatment with more than 2 oral antidiabetic medications, oral semaglutide, or anyinjectable medication in a period of 30 days before the day of eligibilityassessment. Temporary/emergency use of any type of insulin is allowed, as is priorinsulin treatment for gestational diabetes.

• Contraindications to semaglutide according to the Food and Drug Administrationapproved label.

• Female who is pregnant, breastfeeding or intends to become pregnant

• Participation in another clinical trial.