Medtronic Terminate AF Study

Inclusion Criteria:

• History of non-paroxysmal AF (persistent or longstanding persistent)

• Concomitant indication for non-emergent open-heart surgery, eg,

1. Coronary artery bypass grafting

2. Valve repair or replacement

• Able to take the anticoagulant warfarin or novel oral anticoagulants (NOAC)

Exclusion Criteria:

• Wolff-Parkinson-White syndrome

• New York Heart Association (NYHA) Class = IV

• Left Ventricular Ejection Fraction ≤ 30%

• Need for emergent cardiac surgery (ie, cardiogenic shock) or redo open heart surgery

• Previous AF ablation, atrioventricular (AV) -nodal ablation, or surgical Mazeprocedure

• Contraindication for anticoagulation therapy

• Left atrial diameter > 6.0 cm

• Preoperative need for an intra-aortic balloon pump or intravenous inotropes

• Renal failure requiring dialysis or hepatic failure

• Life expectancy of less than 1 year

• Predicted risk of operative mortality >10% as assessed by STS Risk Calculator

• Pregnancy or desire to be pregnant within 12 months of the study treatment

• Current diagnosis of active systemic infection

• Active endocarditis

• Documented MI 30 days prior to study enrollment

• Current or planned participation in an investigational or observational drug ordevice trial related to the treatment of atrial arrhythmias