Effect of Preoperative Intravenous Dexamethasone on Postoperative Pain After Primary Total Hip Arthroplasty

Last updated: May 31, 2018
Sponsor: Chiang Mai University
Overall Status: Active - Recruiting

Phase

4

Condition

Osteoarthritis

Treatment

N/A

Clinical Study ID

NCT03542617
ORT-2559-03928
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

To compare the effects of preoperative intravenous Dexamethasone between 10 mg and 40 mg with placebo on Postoperative Pain After Primary Total Hip Arthroplasty

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age > 18 years

  • Undergoing Elective, Primary, unilateral Total Hip arthroplasty

  • American Society of Anesthesiology (ASA) physical class 1-3

  • BMI < 40 kg/m2

Exclusion

Exclusion Criteria:

  • History of previous musculoskeletal injury on the same hip

  • History of prior surgery on the same unilateral hip

  • History of adverse effects from medication utilized in this study

  • Contraindication to spinal anesthesia

  • History of psychiatric disorders or cognitive impairment

  • Contraindication to Corticosteroid

  • Poorly controlled Diabetes mellitus

  • History of ischemic heart disease or peripheral arterial disease or cerebrovasculardisease

  • Hepatic insufficiency (Child-Pugh score > 5)

  • Renal insufficiency (Creatinine clearance < 30 mL/min)

  • History of cataract or glaucoma or ocular hypertension

Study Design

Total Participants: 57
Study Start date:
October 05, 2016
Estimated Completion Date:
December 31, 2020

Study Description

It still unclear whether the effective dose preoperative intravenous dexamethasone on postoperative pain after Total Hip Arthroplasty. The research hypothesis is that the effect of 10 mg intravenous Dexamethasone in postoperative pain(5 metre walking at 24 hour) is not inferior to 40 mg intravenous Dexamethasone

Connect with a study center

  • Department of Orthopedics, Chiang Mai University

    ChiangMai, 50200
    Thailand

    Active - Recruiting

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