Fish Oil and EPO in Breast Cancer

Last updated: November 2, 2022
Sponsor: University of Belgrade
Overall Status: Active - Recruiting

Phase

N/A

Condition

Breast Cancer

Cancer

Treatment

N/A

Clinical Study ID

NCT03516253
VMA-253-18
  • Ages 45-65
  • Female

Study Summary

Recent literature data suggest beneficial effects of dietary fats in patients with cancers, in particular polyunsaturated fatty acids (PUFAs). Fish oil and evening primrose oil provide a high amount of PUFAs and a desirable n-6/n-3 PUFAs ratio.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Histologically confirmed breast cancer,
  • Clinical Stadium III and IV,
  • Patients able to understand requirements of the study and provide written informedconsent-

Exclusion

Exclusion Criteria:

  • Previous radio- or chemotherapy
  • Other serious chronic diseases
  • Statin therapy
  • Use of fat-based dietary supplements (such as fish oil, evening primrose oil etc) 3months prior to study

Study Design

Total Participants: 60
Study Start date:
February 20, 2019
Estimated Completion Date:
June 20, 2024

Study Description

Breast cancer (BC) is leading cancer in women. As most of the cancers, it is characterized by inflammation and alternations in lipid and fatty acid metabolism. Patients with BC have impaired fatty acid profiles, low level of PUFAs, and high n-6/n-3 PUFAs ratio. Moreover, these changes are related to clinical outcome.

Fish oil is the richest source of anti-inflammatory n-3 PUFAs. Evening primrose oil (EPO) is rich in 18:3 n-6, the only n-6 fatty acid with an anti-inflammatory effect. Dietary intake of fish oil or EPO has been shown to decrease inflammation and improve PUFAs status in patients with cancers. However, it is not known what is the effect of combined EPO and fish oil in BC patients.

The study design is double-blind, controlled, randomized nutritional intervention. The participants are randomly assigned into intervention and control group before starting chemotherapy. All patients receive nutritional counseling to achieve a daily energy and protein intake according to recommended dietary allowances, with (intervention) or without (control) of milled seed mix.

Connect with a study center

  • Military medical academy

    Belgrade, 11000
    Serbia

    Active - Recruiting

  • University of Belgrade

    Belgrade, 11129
    Serbia

    Site Not Available

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