Nitrate Supplementation and Muscle Blood Flow

Last updated: January 8, 2019
Sponsor: University of Iowa
Overall Status: Completed

Phase

N/A

Condition

Aging

Low Blood Pressure (Hypotension)

Treatment

N/A

Clinical Study ID

NCT03459027
201708795
  • Ages 60-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults. All subjects will receive active (rich in dietary nitrate) or placebo (devoid of nitrate) supplementation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy older adults 60-80 years of age

Exclusion

Exclusion Criteria:

  • Hypertension,

  • Smoking,

  • Heart disease,

  • Diabetes,

  • Body mass index (BMI) ≥ 30 kg/m2,

  • Autonomic disorders and other conditions that may alter blood pressure or vascularfunction

  • Medications that might normally alter blood pressure or vascular function.

  • Older women taking hormone replacement therapy medications.

Study Design

Total Participants: 10
Study Start date:
October 10, 2017
Estimated Completion Date:
February 08, 2018

Study Description

Dietary nitrate (beetroot juice) is reduced to nitrite and nitric oxide within the digestive system of humans. Nitric oxide exerts potent vasodilator effects, which have been shown to reduce blood pressure and enhance exercise economy in humans. This pressure reducing effect may have implications within the regulation of blood flow during dynamic exercise in older adults.

Connect with a study center

  • Medical Education Building

    Iowa City, Iowa 52242
    United States

    Site Not Available

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