Endometrial Cancer Lymphadenectomy Trial

Inclusion Criteria:

1. histologically confirmed EC of clinical stages T1b and T2 (all histological types)and stage T1a G3 type 1 (endometrioid, endometriod with squamous differentiation,mucinous) or type 2 tumors (any percentage of serous or clear cell component) orcarcinosarcoma

2. a) no previous surgery concerning EC (primary surgery) or b) surgery afterhysterectomy (e.g. for presumed low risk endometrial cancer) is allowed within 8weeks after hysterectomy if no LNE was performed (secondary surgery)

3. absence of bulky lymph nodes

4. performance status ECOG 0-1

5. age 18 - 75 years

6. written informed consent

7. adequate compliance

Exclusion Criteria:

1. stage pT1a, G1 or G2 tumors of type 1 histology

2. sarcomas (except for carcinosarcoma = malignant mixed Müllerian tumor)

3. EC of FIGO stages III or IV (except for microscopical lymph node metastases)

4. evidence of extrauterine disease by visual inspection

5. recurrent EC

6. preceding chemo-, radio, or endocrine therapy for EC

7. any concomitant disease not allowing surgery including lymphadenectomy and/orchemotherapy

8. any medical history indicating excessive peri-operative risk

9. any current medication containing considerable surgical risk (e.g. bleeding: due tooral anticoagulating agents)

10. any known disorder or circumstances making participation in trial and follow-upquestionable. Insufficient compliance is expected.

11. patients with second malignancies if disease or treatment might have an impact onthe patient's prognosis

12. known HIV-infection or AIDS

13. simultaneous participation in other clinical trials if not permitted by the steeringcommittee (translational or QoL studies not interfering with the objectives of ECLATare allowed)