Cardiovascular Morbidities and Lung Cancer Treatment: a Prospective Registry

Inclusion Criteria:

• Histological diagnosis of lung cancer, either NSCLC or SCLC patients and carcinoidtumours
• Untreated lung cancer of any stage and any treatment (including palliative care only).
• Availability for participating in the detailed follow-up of the protocol.
• Signed informed consent.
• Age above 18 years.
• Presence of at least one co-morbidity:
• Any active or past cardiac ischemia
• Reduced left ventricular ejection fraction (< 50%)
• Obstructive cardiomyopathy
• Valvular dysfunction (3 or 4/4; valvular replacement)
• Arrhythmia (atrial flutter or fibrillation, significant ventricular arrhythmia, 2nd-3rd degree auriculo-ventricular block, Wolf-Parkinson-White and other similaraberrant conduction, bifascicular block, arrhythmogenic right ventricular dysplasia)
• Uncontrolled hypertension (systolic blood pressure (BP) > 160 millimeter of mercury (mmHg) or diastolic BP > 100 mmHg on ≥ 1 hypotensive drug) or controlled hypertensionon ≥ 2 concurrent hypotensive drugs
• Active or treated peripheral arteritis (grade 2 or more)
• Cerebrovascular events
• Pulmonary embolism and/or thrombophlebitis or patients at high risk of thrombophilia (homozygous Leiden factor…)
• Aortic aneurism

Exclusion Criteria:

• Thymoma and thymic malignancies, pleural mesothelioma.
• Patient previously treated for lung cancer.
• Tumours for which complete staging cannot be assessed.
• History of prior malignant tumour, except non-melanoma skin cancer or in situcarcinoma of the cervix or of the bladder or cured malignant tumour (more than 5-yeardisease free interval).