Pregnancy Related Inappropriate Sinus Tachycardia

Last updated: January 18, 2019
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dysrhythmia

Heart Disease

Cardiac Disease

Treatment

N/A

Clinical Study ID

NCT03317249
PRIST
  • Ages 18-45
  • Female
  • Accepts Healthy Volunteers

Study Summary

A feasibility study into the exploration of possible mechanisms underlying inappropriate sinus tachycardia (IST) syndrome in pregnancy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 18-45 years of age

  • Able to give written informed consent and willing to participate

  • The participant falls into one of the below categories: i. Pregnant women with IST ii. Pregnant women without IST

Exclusion

Exclusion Criteria:

  • Obesity (BMI > 29.9)

  • Current or recent (within last 3 months) smoker

  • Known medical condition likely to affect HRV (other than IST in relevant groups)

  • Previous history of hypertensive disorders in pregnancy

  • Lack of written informed consent

Study Design

Total Participants: 200
Study Start date:
October 06, 2017
Estimated Completion Date:
October 06, 2020

Study Description

This is a non-interventional, physiological study which will explore the feasibility of examining autonomic function and related haemodynamic variables in pregnant women with and without inappropriate sinus tachycardia, with the aim of providing scope for future research.

Sinus tachycardia (normal heart rhythm but fast heart rate) is common and usually related to an obvious cause (e.g. exercise such a running or cycling) and doesn't cause any untoward symptoms. In rare cases however, sinus tachycardia can occur without an obvious cause (i.e. it is inappropriate to the situation) and can cause distressing symptoms such as palpitations, dizziness and breathlessness at rest or with minimal exertion. This syndrome of inappropriate sinus tachycardia is poorly understood and can be difficult to manage; especially when the affected individual is pregnant. In order to understand the condition better and improve care pathways we aim to measure various features of the cardiovascular system in pregnant women with and without IST.

Connect with a study center

  • Addenbrookes Hospital

    Cambridge, CB2 0QQ
    United Kingdom

    Active - Recruiting

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