TRAMmoniTTR Study Genetic Screening of an At-risk Population for HATTR and Monitoring of TTR Positive Subjects

Inclusion Criteria:

• Informed consent is obtained from the participant

• The participant is 18 years of age or older

• The participant has no diagnosis of alcoholism according to international guidelines

• The participant has not undergone chemotherapy for any carcinoma

AND

The participant is at risk for hATTR due to two or more the factors listed below:

• cardiomyopathy or polyneuropathy with no obvious etiology atypical Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) or Motor Neuron Disease (MND)

• autonomic dysfunction

• hypertrophic cardiomyopathy or heart failure with preserved ejection fraction Left Ventricular Hypertrophy (LVH)

• bilateral carpal tunnel syndrome

• spinal stenosis or spinal radiculopathy

• gait disorders

• ocular changes involving vitreous opacities

• unexplained weight loss >5kg

• renal abnormalities

• family history of hATTR

• based on imaging or biopsy suspected for the wild type TTR (ATTR) and not genetically tested for hATTR

OR • The participant is diagnosed with hATTR

OR

• The participant is a 1st or 2nd degree relative of the TTR positive subject

Exclusion Criteria

• Informed consent is not obtained from the participant

• The participant is younger than 18 years of age

• The participant has a diagnosis of alcoholism according to International guidelines

• The participant has undergone chemotherapy for any carcinoma

• The participant is not at risk for hATTR