Grasping Rehabilitation Using Motor Imagery With or With no Neurofeedback After Tetraplegia

Last updated: September 28, 2023
Sponsor: Hospices Civils de Lyon
Overall Status: Active - Recruiting

Phase

N/A

Condition

Limb Spasticity

Treatment

Motor imagery combined with neurofeedback (MINF)

Control (C)

Motor imagery (MI)

Clinical Study ID

NCT03190863
69HCL17_0016
  • Ages 18-55
  • All Genders

Study Summary

Motor imagery has shown promising results to optimize tenodesis grasp in individuals with C6-C7 tetraplegia. However, efficacy of using motor imagery to improve grasping after tetraplegia requires further study with higher level of evidence. In addition, controlling covert practice remains difficult due to the absence of overt movements. However, similar brain activity measured during both over and cover movements makes possible to provide visual information about the covert practice performance using neurofeedback.

The Investigators thus designed this multicentric randomized controlled trial to investigate the effect of motor imagery with or with no visual neurofeedback on grasping capabilities after C6-C7 tetraplegia. They hypothesized that providing neurofeedback based on brain activity measured by electroencephalography namely knowing the covert practice performance would results in greater grasping improvement in response to practice as compared to motor imagery practice alone.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Volunteer individuals with C6-C7 tetraplegia with complete finger flexor paralysisrestricting grasping capabilities to the tenodesis.
  • Consent to participate to the study after receiving clear, loyal and appropriateinformation.
  • Aged between 18 and 55 years.
  • Time since spinal cord injury above 6 months
  • Stabilized condition in particular sensori-motor deficit.
  • Sitting position for more than 1 hour
  • Able to imagine movement
  • Health care beneficiary

Exclusion

Exclusion Criteria:

  • Long-lasting autonomic disorders while sitting (orthostatic hypotension and/or bloodpressure instability) limiting sitting position to less than 1 hour.
  • Upper limb pain for either mechanic or neuropathic reasons preventing all graspingmovement and/or the ability to imagine those movements.
  • Restricted wrist and finger range of motion preventing the tenodesis grasp.
  • Patient after surgical tendon transfer that improved grasping capabilities (e.g.active finger flexion).
  • Ongoing participation in another research that aim to evaluate an intervention likelyto improve the neurological or functional recovery introducing an experimental bias.
  • Specific contraindication to Magnetoencephalography with the presence of metallicfragments inside the body such as pace-maker, neurostimulator, cochlear implants,steel dental implant and osteosynthesis material only applicable to the participantsincluded in Lyon hospital center (n=15).

Study Design

Total Participants: 21
Treatment Group(s): 3
Primary Treatment: Motor imagery combined with neurofeedback (MINF)
Phase:
Study Start date:
March 29, 2018
Estimated Completion Date:
May 29, 2025

Connect with a study center

  • Le Centre Mutualiste Neurologique PROPARA, Parc Euromédecine

    Montpellier, 34090
    France

    Active - Recruiting

  • Service de médecine physique et de réadaptation, Hôpital Henry Gabrielle

    Saint-Genis-Laval, 69230
    France

    Active - Recruiting

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