INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients

Last updated: April 3, 2024
Sponsor: Dr. J. Werier
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sarcoma

Treatment

Incisional Negative Pressure Wound Therapy (INPWT)

Wound Dressing

Clinical Study ID

NCT03175718
20170154
  • Ages > 18
  • All Genders

Study Summary

Project Summary - Aggressive soft tissue cancers are commonly treated with radiation followed by surgery. These wounds have a very high rate of wound complications and infection (30%), resulting in more surgeries, longer hospital stays and complex nursing care. Previous research shows that negative pressure (vacuum) dressings applied to the incision at the end of surgery can reduce these complications. The Investigator and his team across Canada will perform a clinical trial comparing standard dressings to these vacuum dressings. The results of this study have the potential to immediately improve the quality of life of soft tissue cancer patients. It can also decrease the amount of time required in hospital and reduce the cost to the Canadian healthcare system.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients 18 years of age and older and are able to provide written consent.
  • Patients with lower extremity soft tissue sarcoma confirmed by tissue pathology.Eachpatient must have local cross sectional imaging (CT or MRI) and a staging CT chest.
  • Patients eligible for treatment with preoperative radiation therapy followed by limbsalvage surgery.
  • Patients for which a primary closure must be attained at the time of surgery.
  • Patient must be available for postoperative follow-up at the treating center.

Exclusion

Exclusion Criteria:

  • Patients who are less than 18 years of age.
  • Patients with a benign disease or with prior radiation to the anatomic region in theremote past (not associated with current treatment radiation plans).
  • Patients who underwent surgical amputation
  • Patients in which primary closure was not achieved (including free flaps and splitthickness skin grafts).
  • Patients with a life expectancy less than 120 days.
  • Patients who have an allergy or sensitivity to adhesive dressings.

Study Design

Total Participants: 291
Treatment Group(s): 2
Primary Treatment: Incisional Negative Pressure Wound Therapy (INPWT)
Phase:
Study Start date:
February 01, 2022
Estimated Completion Date:
April 28, 2026

Study Description

This is a multi-center randomized clinical trial lead by the Investigator from the Ottawa Hospital and six other orthopedic cancer centers. The Investigator and the team will be recruiting 248 patients diagnosed with soft tissue cancer who will be treated with radiation therapy followed by surgery. Each of these patients will be randomly assigned to receiving either 7 days of vacuum dressing (Incisional Negative Pressure Wound Therapy) or a standard dressing. Besides this, patients will receive as identical care as possible. The team will then closely follow these patients over a period of 4 month to examine differences in wound complications, length of hospital stay, patient quality of life, patient satisfaction and function. Statistical analysis will be completed by The Ottawa Methods Center and ethical approval will be obtained at each participating site.

Connect with a study center

  • The Ottawa Hospital

    Ottawa, Ontario K1H 8L6
    Canada

    Active - Recruiting

  • McGill University Health Center

    Montréal, Quebec
    Canada

    Active - Recruiting

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