The Role of Synovitis in Osteoarthritis

Last updated: February 9, 2020
Sponsor: Taipei Veterans General Hospital, Taiwan
Overall Status: Active - Recruiting

Phase

N/A

Condition

Rheumatoid Arthritis

Soft Tissue Infections

Osteoarthritis

Treatment

N/A

Clinical Study ID

NCT03167333
2017-03-009B
  • Ages 45-75
  • All Genders

Study Summary

To determine whether platelet-rich-plasma (PRP) or HA (hyaluronic acid)injection into synovitis in osteoarthritis(OA) knee can achieve improvement in knee function and reduce synovitis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • diagnosed with OA knee according to ACR guideline

  1. stiffness less than 30min

  2. cracking sound during activity

  3. more than 30min pain for last 2 months

  4. non-bed ridden patients

  5. no structure abnormality

  6. synovitis was proved by US

Exclusion

Exclusion Criteria:

  1. OA knee secondary to other disease 2 . more than 10 years after diagnosing OA 3. underknee surgery within 3 months 4. autoimmune disease 5. refuses inform/consent process

Study Design

Total Participants: 100
Study Start date:
March 01, 2020
Estimated Completion Date:
March 01, 2020

Study Description

Methods:

sixty patients with OA knee having unilateral or bilateral synovitis validated by ultrasound (N=40) were studied. All the patients were randomized to receive PRP (N=40) or Hyaluronic acid(HA)(N=40) injection twice at 2-week intervals; Clinical assessments were performed using a visual analog scale(VAS) and The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC index) before injection at baseline, 4 weeks(first evaluation) and 12 weeks(secondary evaluation). Imaging evaluation based on color Doppler ultrasound(CDUS) and the depth of synovial fluid accumulation ,and the width of synovial hypertrophy was performed simultaneously.

Connect with a study center

  • Taipei veteran general hospital yuli branch

    Hualien City, 886
    Taiwan

    Active - Recruiting

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