Validation of a Fetal Urine Peptidome-based Classifier to Predict Post-natal Renal Function in Posterior Urethral Valves

Last updated: August 22, 2023
Sponsor: University Hospital, Toulouse
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT03116217
16/8805
2016-A01914-47
  • Ages 18-65
  • Female

Study Summary

Validate the use of fetal urine peptidome-analysis and explore amniotic fluid markers for the stratification of fetuses with Posterior Urethral Valve for post-natal renal function.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • male singleton fetus with megabladder associated with urinary tract anomalies with orwithout dysplastic or hyperechogenic parenchyma detected in a first ultrasound;
  • megabladder confirmed in a second ultrasound;
  • collection of fetal urine taken during the routine management of the disease for thedosage of ß2-microglobulin;
  • written informed consent.

Exclusion

Exclusion Criteria:

  • refusal to participate in the study;
  • person protected by law.

Study Design

Total Participants: 400
Study Start date:
June 26, 2017
Estimated Completion Date:
December 26, 2023

Study Description

The ANTENATAL project requires the use of fetal urine as well as post-natal urine, post-natal serum and, possibly, amniotic liquid. We will take an additional tube during the takings collected for routine management of the disease.

The analysis of samples will be carried out in Toulouse at the Institute of Metabolic and Cardiovascular Diseases or with fee-for-service suppliers.

Connect with a study center

  • UZ Leuven

    Leuven, 3000
    Belgium

    Site Not Available

  • CHU Pellegrin-Bordeaux

    Bordeaux, 33078
    France

    Site Not Available

  • CHRU de Brest - Hôpital Morvan

    Brest, 29609
    France

    Site Not Available

  • Hôpital Femme Mère Enfant-Lyon

    Bron, 69677
    France

    Site Not Available

  • CH René-Dubos

    Cergy Pontoise, 95303
    France

    Site Not Available

  • CHU Estaing

    Clermont-Ferrand, 63100
    France

    Site Not Available

  • CHU de Grenoble - Hôpital Couple-Enfant - Département de la Génétique

    Grenoble, 38043
    France

    Site Not Available

  • CHU de la Timone

    Marseille, 13385
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Montpellier

    Montpellier, 34295
    France

    Site Not Available

  • Hôpital mère-enfant pédiatrie

    Nantes, 44093
    France

    Active - Recruiting

  • CHU Lenval

    Nice, 06200
    France

    Site Not Available

  • AP-HP - Hôpital Necker Enfants malades

    Paris, 75015
    France

    Site Not Available

  • Hôpital Robert-Debré

    Paris, 75019
    France

    Site Not Available

  • CHU Poitiers

    Poitiers, 86021
    France

    Site Not Available

  • CHU Rennes Hôpital Sud

    Rennes, 35000
    France

    Site Not Available

  • CHU Hôpitaux de St-Etienne-Hôpital Nord

    Saint Etienne, 42055
    France

    Site Not Available

  • Centre hospitalier universitaire Chu Amiens Salouël Hôpital sud

    Salouel, 80480
    France

    Site Not Available

  • Sihcus-Cmco

    Schiltigheim, 67300
    France

    Active - Recruiting

  • Hôpital Bagatelle (Talence) - CHU Pellegrin (Bordeaux)

    Talence, 33400
    France

    Site Not Available

  • Hôpital Paule de Viguier-Hôpital des enfants- Site Purpan

    Toulouse, 31059
    France

    Active - Recruiting

  • Centre Olympe de Gouges du CHRU de Tours

    Tours, 37000
    France

    Site Not Available

  • Heidelberg University Hospital

    Heidelberg, 60120
    Germany

    Site Not Available

  • Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico

    Milan,
    Italy

    Site Not Available

  • Leiden University Medical Center Dept of prenatal diagnosis and therapy

    Leiden, The Netherlands 2333
    Netherlands

    Site Not Available

  • Radboudumc Amalia Children's Hospital

    Nijmegen, The Netherlands 6500
    Netherlands

    Site Not Available

  • Polish Mothers Memorial Hospital Research Institute

    Lodz, 93-338
    Poland

    Site Not Available

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035
    Spain

    Site Not Available

  • Hôpital des Enfants Hôpitaux universitaire Genève (HUG)

    Geneve, Switserland CH-1211
    Switzerland

    Site Not Available

  • FetalMedicine Centre Birmingham Women's Hospital

    Birmingham, B15 2TG
    United Kingdom

    Site Not Available

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