Study of Food Aversion in Patients With Anorexia Nervosa

Last updated: November 9, 2023
Sponsor: University of California, San Diego
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vomiting

Anorexia

Treatment

A breakfast sandwich

Clinical Study ID

NCT03100656
R01MH106781
  • Ages 18-55
  • Female
  • Accepts Healthy Volunteers

Study Summary

This study uses a meal-challenge protocol to assess if patients with anorexia nervosa show a differential metabolism in response to food in comparison to healthy controls. This study determines how heritable and biochemical factors influence food metabolism in anorexia nervosa in order to develop more effective treatment strategies.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Ill AN subjects will meet current Diagnostic and Statistical Manual of MentalDisorders (DSM V) diagnosis of AN, body mass index (BMI) between 11 kg/m² and 17.5kg/m², or BMI > 17.5 kg/m² with active eating disorder symptoms.
  • Recovered AN must meet the following criteria at time of study entry: 1) Current orpast DSM V diagnosis of AN; 2) BMI between 18.5 kg/m2 and 30 kg/m2; 3) Havingmaintained a BMI of >18.5 for at least one year.
  • Control must be healthy adolescent or woman negative on our screen for AN, other AxisI psychiatric illnesses, and having maintained a BMI of between 18.5-30 kg/m² sincethe age of 18.

Exclusion

Exclusion Criteria:

  • Exclusion criteria for AN and control subjects include: Organic brain syndrome,schizophrenia and schizoaffective disorder, untreated thyroid disease, renal disease,hepatic disease, and the regular use of fish-oil containing supplements within thelast three months of the study. All pregnant and lactating individuals will beexcluded.

Study Design

Total Participants: 300
Treatment Group(s): 1
Primary Treatment: A breakfast sandwich
Phase:
Study Start date:
November 10, 2016
Estimated Completion Date:
December 31, 2026

Study Description

Anorexia nervosa is a brain-based disorder that often leads to serious health consequences including death. The EPHX2 gene has been identified as a susceptibility gene for anorexia nervosa. This study utilizes a multi-omics biomarker system approach to investigate how genetic factors interact with dietary factors to influence food aversion, psychopathology, and clinical outcome in patients with anorexia nervosa.

Connect with a study center

  • Program for Eating Disorders, Toronto General Hospital

    Toronto, Ontario
    Canada

    Active - Recruiting

  • UC San Diego Altman Clinical and Translational Research Institute

    La Jolla, California 92037
    United States

    Active - Recruiting

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