A Case Control Study to Identify the Role of Epigenetic Regulation of Genes Responsible for Energy Metabolism and Mitochondrial Function in the Obesity Paradox in Cardiac Surgery

Last updated: November 9, 2023
Sponsor: University of Leicester
Overall Status: Active - Recruiting

Phase

N/A

Condition

Diabetes Prevention

Obesity

Treatment

N/A

Clinical Study ID

NCT02908009
0574
  • Ages > 16
  • All Genders

Study Summary

This is a prospective, single-centre case control comparison of expression of target genes responsible for energy utilisation, mitochondrial function and oxidative stress and levels of histone acetylation/ DNA methylation in obese and non-obese adult cardiac surgery patients. The study aims to test several inter-related hypotheses in a consecutive sequence of patients undergoing coronary artery bypass grafting.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with pre-existing paroxysmal, persistent or chronic atrial fibrillation,

Exclusion

Exclusion Criteria:

  • Patients with pre-existing inflammatory state: sepsis undergoing treatment, acutekidney injury within 5 days, chronic inflammatory disease, congestive heart failure.
  • Emergency or salvage procedure.
  • Ejection fraction <30 %.
  • Patient in a critical preoperative state (Kidney Disease: Improving Global Outcomes (KDIGO) Stage 3 AKI [20] or requiring inotropes, ventilation or intra-aortic balloonpump).
  • Pregnancy.

Study Design

Total Participants: 80
Study Start date:
September 09, 2016
Estimated Completion Date:
October 07, 2024

Connect with a study center

  • England

    Glenfield, Leicestershire LE3 9QP
    United Kingdom

    Active - Recruiting

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