Effects of Melatonin in PCOS Women

Last updated: December 3, 2016
Sponsor: Catholic University of the Sacred Heart
Overall Status: Trial Status Unknown

Phase

N/A

Condition

Reproductive Health

Polycystic Ovarian Syndrome

Treatment

N/A

Clinical Study ID

NCT02663570
Melatonina15
  • Ages 18-35
  • Female

Study Summary

The aim of our study is to investigate the effects of a treatment with melatonin on clinical, endocrine and metabolic features in women affected by PCOS. The study group included 40 patients treatend with 2 mg of melatonin daily for six months. Menstrual pattern, anthropometric parameters, hirsutism score, ultrasound ovarian volume and antral follicular count, an oral glucose tollerance test and hormonal assays are evaluated before and after therapy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • women with PCOS in accordance with Rotterdam criteria

Exclusion

Exclusion Criteria:

  • pregnancy

  • past history of cardiovascular diseases

  • diabetes mellitus (or impaired glucose tolerance as determined by a standard 75 groral glucose tolerance test)

  • hypertension

  • significant liver or renal impairment

  • other hormonal dysfunction (hypothalamic, pituitary, thiroidal or adrenal)

  • neoplasms

Study Design

Total Participants: 40
Study Start date:
June 01, 2015
Estimated Completion Date:

Connect with a study center

  • Catholic university of Sacred Heart

    Rome, 00168
    Italy

    Active - Recruiting

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