CDP-choline Treatment in ATS Users

Last updated: July 28, 2022
Sponsor: Ewha Womans University Mokdong Hospital
Overall Status: Active - Recruiting

Phase

2

Condition

Addictions

Opioid Use Disorder

Mood Disorders

Treatment

N/A

Clinical Study ID

NCT02630069
NIH_ATS
  • Ages 14-40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study is a 12-week, randomized, double-blind, placebo-controlled trial of cytidine-5'-diphosphate choline in amphetamine-type stimulants-using adolescents.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 14-40 years
  • Amphetamine (or amphetamine-like) use disorder (DSM-IV-TR)
  • Informed consent
  • Seeking treatment

Exclusion

Exclusion Criteria:

  • Major medical or neurological illnesses
  • Psychiatric illnesses requiring hospitalization, prescription of psychotropicmedications, or emergency psychiatric interventions
  • Current and past diagnosis of a psychotic disorder, bipolar disorder, conductdisorder, or attention-deficit hyperactivity disorder
  • Occasional ATS use (less than monthly use)
  • IQ of 80 or lower
  • Pregnancy or breastfeeding
  • Clinically significant suicidal or homicidal ideation
  • Substance use disorders (substances other than amphetamine or MA)

Study Design

Total Participants: 160
Study Start date:
March 01, 2015
Estimated Completion Date:
December 31, 2022

Study Description

This study is a 12-week, randomized, double-blind, placebo-controlled trial of cytidine-5'-diphosphate choline (CDP-choline) in amphetamine-type stimulants-using adolescents. Multi-level assessments will be performed to determine whether CDP-choline administration with supportive psychotherapy, compared to placebo administration with supportive psychotherapy, will 1) repair ATS-induced neural cell damage of the target brain regions, 2) improve cognitive deficits and normalize the relevant target neural circuits, and then 3) reduce ATS-taking behaviors in ATS-using adolescents.

Connect with a study center

  • Ewha Womans University Mokdong Hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

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