Hepatic Resection Versus TACE+RFA for BCLC Stage B Hepatocellular Carcinoma

Inclusion Criteria:

1. Hepatocellular Carcinoma diagnosed by biopsy or imaging criteria (CT/MRI) and AFP

2. Signed informed consent before registration on study

3. Child-Pugh class A or B

4. Eastern Cooperative Oncology Group Performance status between 0 and 2.

5. BCLC stage B ( diameter of the single tumor ≥5cm or number of tumors ≥3)

6. Hepatitis B history or HBsAg positive

7. Age between 18 and 65 years

8. No previous treatment

9. Laboratory examination test: Platelet count ≥100×109/L; ALT/AST ≤ 3 x ULN; Cr1.5≤ xULN; INR < 1.5 or PT< ULN +4s; Alb≥30g/L; Tbil≤34mmol/L

10. For patients in Hepatic resection group: radical surgery will be performed: (1) Nosegmental, lobar or main portal vein and bile duct thrombosis; (2) no lymph nodesmetastasis; (3) no extra hepatic metastasis.

Exclusion Criteria:

1. cachexia or poor physical condition;

2. pregnant or HCG positive;

3. Portal vein and bile duct thrombosis or with extra hepatic metastasis.

4. Uncontrolled or refractory ascites or history of hepatic encephalopathy

5. Severe heart, brain or kidney diseases

6. hemophilia or patients with coumarin derivative therapy.

7. .history of organ transplantation or mental disease.

8. Be allergic to adriamycin, lobaplatin, mitomycin or iodized oil