Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Last updated: March 29, 2024
Sponsor: University of Colorado, Denver
Overall Status: Active - Recruiting

Phase

N/A

Condition

Down's Syndrome

Mild Cognitive Impairment

Dementia

Treatment

N/A

Clinical Study ID

NCT02612376
15-1774
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study plans to establish a large bank of blood, cerebral spinal fluid (CSF), imaging, and clinical data. These data and samples will be used for future research into the causes of Alzheimer's disease (AD), Down Syndrome (DS) and other diseases that cause thinking and memory problems. This future research will also study how treatments for these diseases work. This research may help develop new treatments for some diseases of the nervous system and help understand these diseases better.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Persons with age-related MCI or AD according to clinical diagnosis, consistent withNIA-AA diagnostic criteria
  2. Community-dwelling controls, Age > 60 years
  3. Ability to complete baseline assessments
  4. Has an informant (study partner) available to complete functional interviews/surveymeasures annually

Exclusion

Exclusion Criteria:

  • Presence of concomitant medical, neurological, or psychiatric illness or conditionthat in the opinion of the investigators would confound interpretation of studyresults. These include: Korsakoff encephalopathy; active substance abuse; hepatitis C;opportunistic brain infection; brain tumor; active neoplastic disease (skin tumorsother than melanoma are not exclusionary; participants with stable prostate cancer maybe included at the discretion of the project director); multiple sclerosis; history ofclinically significant stroke; current evidence or history in the past 2 years offocal brain lesion, head injury with loss of consciousness, or DSM-V criteria for anymajor psychiatric disorder, including psychosis, major depression, bipolar disorder,alcohol or substance abuse; blindness, deafness or any other disability which mayprevent the participant from participating or cooperating in the protocol.
  • Presence of contraindication for MRI scan

Study Design

Total Participants: 800
Study Start date:
February 01, 2016
Estimated Completion Date:
January 31, 2025

Connect with a study center

  • University of Colorado, Denver

    Aurora, Colorado 80045
    United States

    Active - Recruiting

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