Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreas

Inclusion Criteria:

• Biopsy proven unresectable adenocarcinoma of the pancreas.

• Have either unresectable, borderline resectable or medically inoperable carcinoma ofthe pancreas, or refusing surgery.

• A biliary obstruction is able to participate as long as a drainage tube is in placeprior to starting treatment with Proton radiation,

• Participants of child-producing potential must be willing to use contraception whileon treatment and for at least 12 months thereafter.

• Required pretreatment laboratory parameters:

• Absolute granulocyte count (AGC/ANC) ≥ 1.8 thou/mm3

• Platelet count ≥ 100,000/mm3

• Bilirubin < 2 mg/dl

• ALT/SGPT < 3x upper limit of normal

• Creatinine < 3 mg/dl

Exclusion Criteria:

• Evidence of distant metastasis.

• Prior surgical resection.

• Previous history of invasive malignancy (except non-melanoma skin cancer and low tointermediate risk prostate cancer) unless the participant has been disease free for 5 years prior to registration.

• Active or untreated infection,

• Pregnant or breastfeeding women or subjects of child producing potential not willingto use medically acceptable contraception while on treatment and for at least 12months thereafter.

• Previous Radiation to the abdomen.