Combined Modality Therapy in Hepatoblastoma: South Egypt Cancer Institute Experience

Last updated: July 21, 2023
Sponsor: Assiut University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hepatoblastoma

Treatment

N/A

Clinical Study ID

NCT02557750
Comb Mod Hepatoblastoma SECI
  • Ages < 18
  • All Genders

Study Summary

The aim of this study is to retrospectively investigate the effect of combined modality treatment of pediatric hepatoblastoma and the factors affecting the prognosis in accordance with the experience at the pediatric oncology department at South Egypt Cancer Institute.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients whose age less than 19 years.
  • Patients diagnosed with hepatoblastoma.

Exclusion

Exclusion Criteria:

  • Patients whose age more than 18 years.

Study Design

Total Participants: 35
Study Start date:
January 01, 2016
Estimated Completion Date:
October 31, 2023

Study Description

Background:

Hepatoblastoma (HB) is the most common malignant liver tumor in children, with an incidence of 0.7 to 1 per million children <15 years of age. Till 1970s, surgery was the primary modality of treatment of HB. Unfortunately, up to 60% of the patients present in an unresectable stage. Later, the chemo- responsiveness of the tumor was demonstrated which led to the incorporation of adjuvant chemotherapy with cisplatinum and doxorubicin in the treatment of HB. International Society of Pediatric Oncology (SIOP) pioneered the concept of neoadjuvant chemotherapy in the management of HB.

Patients & Methods:

In the period from 2002 January till 2016 January, retrieval & analysis of the medical records of pediatric patients with hepatoblastoma will be made at the pediatric oncology department, South Egypt Cancer Institute which represents the largest referral center in Upper Egypt. After pathologic confirmation of the diagnosis, these data will be categorized according to patients' demographics, presenting features, laboratory studies, including tumor markers & histologic subtype, radiographic evaluation, disease staging, treatment course given, and subsequent treatment outcomes.

Connect with a study center

  • Assiut University

    Assiut, 71515
    Egypt

    Active - Recruiting

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