Intra-operative Radiotherapy For Women With Ductal Carcinoma in Situ Breast Cancer

Last updated: March 10, 2015
Sponsor: Liao Ning
Overall Status: Active - Recruiting

Phase

N/A

Condition

Carcinoma

Breast Cancer

Genitourinary Cancer

Treatment

N/A

Clinical Study ID

NCT02389673
GGHBCRG-IORT-DCIS
  • Ages 18-70
  • Female

Study Summary

Whether the patients with low grade ductal carcinoma in situ breast cancer should accept radiationtherapy is uncertain.Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation during surgery followed by external-beam radiation to the entire breast may kill more tumor cells.The clinical trial is conducting to find out the effectiveness of radiation therapy during surgery in treating women who have undergone breast-conversing surgery for low grade ductal carcinoma in situ breast cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Tumor diameter < 5 cm

  • Low grade ductal carcinoma in situ

  • Candidate for breast-conserving surgery

  • Must have undergone lumpectomy with negative margins or minimal margin involvement

  • Currently undergoing re-excision of the biopsy cavity and/or sentinel lymph nodebiopsy or axillary lymph node dissection

  • No evidence of metastatic disease

  • Informed consent

Exclusion

Exclusion Criteria:

  • No informed consent

  • Tumor size > 5 cm

  • Intermediate or high grade ductal carcinoma in situ

  • Invasive carcinoma

  • No indication for a boost

Study Design

Total Participants: 222
Study Start date:
October 01, 2014
Estimated Completion Date:
June 30, 2026

Study Description

Giving radiation during surgery followed by external-beam radiation to the entire breast may kill more tumor cells.The clinical trial is conducting to find out the effectiveness of radiation therapy during surgery in treating women who have undergone breast-conversing surgery for low grade ductal carcinoma in situ breast cancer.

Connect with a study center

  • Guangdong Academy of Medical Sciences

    Guangzhou, Guangdong 510080
    China

    Active - Recruiting

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