Inflammation and Post-Stroke Depression

Phase

N/A

Condition

Inflammation

Depression

Stroke

Treatment

N/A

Clinical Study ID

NCT02368145

2012001658

pc 62-12

Ages > 18
All Genders

Study Summary

This study is being done to see if there is a relationship between stroke, post-stroke depression, and measures of inflammatory and/or stress compounds in the blood. Brain injury, as caused by stroke, leads to an inflammatory response in the brain which in turn can influence inflammatory and stress responses in other parts of the body outside of the brain. These responses can be measured by analyzing various substances in the blood and in the white blood cells. The investigators will measure these substances (cytokines, glucocorticoids) and compare them to the absence, presence, or degree of depression that the investigators will determine by neurological and psychological testing. The investigators will be drawing blood for this study on admission, at or around day 3, at or around day 7 and at or around day 90, which is not part of routine stroke care. The investigators will be asking subjects to participate in answering question/scales on these same days, some of these questionnaires are also not part of routine stroke care. Standard stroke care is being done other than blood drawing/participating in answering questions/scales. Approximately 25 people will be enrolled over one year.

Eligibility Criteria

Inclusion

Inclusion Criteria:

The subjects will be male and female patients with acute ischemic stroke of the brain.Vascular risk factors, including diabetes, hypertension, and coronary artery disease,are expected to be common, and will be recorded in the Source Documents (appendix).Patients will be included if:
Aged ≥ 18 years of age
Neuroimaging or clinical symptoms are consistent with an acute ischemic stroke (AIS)
There are no alternative explanations for symptoms (eg. tumor, witnessed seizure,history of complicated migraine headache, hypoglycemia [blood sugar (BS) < 50mg/dL] or hyperglycemia (BS > 400 mg/dL)
Subject is able to be enrolled and have blood samples drawn (Note: inability toprovide a sample within 48 hours does not preclude inclusion if consent isprovided after this time and patient can provide blood at subsequent time points (see Table)
Subject is able to provide informed consent for participation in this researchstudy

Exclusion

Exclusion Criteria:

• Other known severe/terminal illness which limits life expectancy to < 90 days,sepsis, disseminated intravascular coagulopathy (DIC), infective endocarditis,metastatic cancer, or cerebral vasculitis
Current diagnosis of or treatment for major depressive disorder
Women who are pregnant at the time of stroke, since pregnancy alters inflammatorymarkers
Communication problems due to aphasia at visit 2, inability to speak English
History of substance abuse and other relevant psychiatric conditions
Autoimmune, current or recent infection, hematological disorders, use of immunemodulating drugs

Study Design

July 01, 2013

December 31, 2015

Study Description

Depression is a common long-term outcome of acute ischemic stroke (AIS), and can impede recovery, increase stroke recurrence, and influence mortality from stroke. Based on literature reviewed below, the investigators propose the novel over-arching hypothesis: that post-stroke depression (PSD) occurs in patients who show elevated production of proinflammatory immune cytokines during and/or after stroke, and at the same time present with reduced sensitivity to the immunosuppressive effects of glucocorticoids, which otherwise would be expected to have down-regulated cytokine production.

Connect with a study center

Rutgers, The State University
New Brunswick, New Jersey 08901
United States
Site Not Available

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