Hypoglossal Acupuncture for Dysgeusia in Patients Undergoing Chemotherapy

Last updated: March 25, 2025
Sponsor: Universität Duisburg-Essen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cancer

Chemotherapy

Treatment

Hypoglossal acupuncture

Sham acupuncture

Dietary recommendations

Clinical Study ID

NCT02304913
14-5953-BO
  • Ages > 18
  • All Genders

Study Summary

This randomized controlled trial aims to investigate hypoglossal acupuncture in comparison to sham acupuncture and standard medical treatment (dietary recommendations) in the treatment of dysgeusia in cancer patients undergoing chemotherapy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Initial treatment with platinum-containing or taxane-based CTX (regardless of thethe length of the CTX cycle)

  • Senological, gynecological or internistic tumors

  • Phantogeusia (on average ≥4 NRS)

  • Willingness to participate in the study and written informed consent

Exclusion

Exclusion Criteria:

  • Severe stomatitis

  • Dysgeusia before the CTX based on neurological diseases, diabetes, or the ingestionof drugs with taste disorders as side effects

  • Leucopenia/neutropenia

  • Intake of anticoagulants

  • Smoking

  • Severe physical or mental comorbidity (due to which the patient is unable toparticipate in the study)

  • Participation in other CAM treatments within the integrative oncology care

  • Participation in other studies on the effectiveness of interventions for oralcomplications

Study Design

Total Participants: 75
Treatment Group(s): 3
Primary Treatment: Hypoglossal acupuncture
Phase:
Study Start date:
January 01, 2015
Estimated Completion Date:
December 31, 2026

Study Description

Taste disorders are frequent side effects in patients undergoing chemotherapy (CTX). Dysguesia has prevalence rates of 16% to 1000% during CTX with sometimes also persistent courses. Impact of dysguesia on appetite, body weight as well as health-related quality of life was shown. Until now, evidence for adequate treatment options is limited to specific diary recommendations. Acupuncture in the treatment of side effects of chemotherapy was investigated for nausea and xerostomia, but not for dysguesia. Therefore, this randomized controlled trial aims to investigate hypoglossal acupuncture in comparison to sham acupuncture and standard medical treatment (dietary recommendations) in the treatment of dysgeusia in cancer patients undergoing chemotherapy.

Connect with a study center

  • Department of Gynecology & Gynecologic Oncology, Evang. Kliniken Essen-Mitte

    Essen, NRW 45136
    Germany

    Site Not Available

  • Department of Senology, St. Josef's Hospital Hilden

    Hilden, 40724
    Germany

    Site Not Available

  • Universitätsklinikum Mannheim, Internistische Onkologie

    Mannheim, 68167
    Germany

    Active - Recruiting

  • Robert Bosch Krankenhaus Stuttgart

    Stuttgart, 70376
    Germany

    Site Not Available

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