OCT Angiography in Wet AMD

Last updated: February 8, 2024
Sponsor: Oregon Health and Science University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Geographic Atrophy

Macular Degeneration

Treatment

Optical Coherence Tomography

Clinical Study ID

NCT02253030
IRB#000010535
  • Ages 50-100
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to:

  1. diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD)

  2. evaluate patients undergoing treatment for wet AMD

  3. determine if reduced flow to the choroid is a risk factor for developing wet AMD.

Eligibility Criteria

Inclusion

Inclusion Criteria (Groups with wet AMD):

  • Adults aged 50 and older with clinical findings of treatment-naïve (never treated) neovascular AMD with active new blood vessel growth confirmed by clinical testing will be considered

Inclusion Criteria (Group with healthy eyes)

  • No evidence of retinal disease

  • Refractive error greater than +3.00 diopters or -7.00 diopters (glasses Rx)

  • No recent eye surgery in the last 4 months

  • No significant cataract to interfere with the quality of the imaging

Exclusion Criteria (All Groups):

  • Inability to give informed consent

  • Significant kidney disease

  • Blood pressure greater than 180/110

  • Previous macular laser treatment

  • Inability to maintain stable fixation during OCT imaging

  • Visual acuity worse than 20/200

Study Design

Total Participants: 160
Treatment Group(s): 1
Primary Treatment: Optical Coherence Tomography
Phase:
Study Start date:
September 01, 2014
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Casey Eye Institute, Oregon Health & Science University

    Portland, Oregon 97239
    United States

    Active - Recruiting

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