Preoperative Concurrent Chemoradiotherapy for Locally Advanced Gastroesophageal Junction or Upper Gastric Adenocarcinoma

Last updated: June 4, 2015
Sponsor: Peking University
Overall Status: Active - Recruiting

Phase

2/3

Condition

Adenocarcinoma

Esophageal Disorders

Digestive System Neoplasms

Treatment

N/A

Clinical Study ID

NCT02193594
CRADLE
  • Ages 18-80
  • All Genders

Study Summary

Preoperative chemoradiotherapy(CRT) had been introduced in the comprehensive treatment of gastroesophageal junction and upper gastric cancers in the decade.According to some researches,CRT had shown its good curative effects in local control and prolonged overall survival.However,the optimization scheme for CRT and its influence to surgery remains controversial.Meanwhile,there were many design flaws in the past few research,such as the lack of adjuvant chemotherapy,the insufficiency in lymphnodes dissection.We decided to carry out the trial,eliminating all the bias as far as we can,to illustrate the efficacy and safety of CRT.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Histologically proven adenocarcinoma of the gastroesophageal junction.

  • Clinical stage diagnosed by endoscopic ultrasound(EUS) or computed tomography(CT) asT3-4NxM0 tumors,according to American Joint Committee on Cancer (AJCC) 7th edition.

  • Eastern Cooperative Oncology Group (ECOG) performance status≤2.

  • Informed consent obtained.

Exclusion

Exclusion Criteria:

  • Combined with other malignant tumors.

  • Eastern Cooperative Oncology Group (ECOG) performance status＞2.

  • Combined with severe organ dysfunction.

  • Pregnancy

Study Design

Total Participants: 214
Study Start date:
January 01, 2014
Estimated Completion Date:
May 31, 2020

Connect with a study center

  • Beijing Cancer Hospital

    Haidian District, Beijing 100142
    China

    Active - Recruiting

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