Alzheimer's Disease Core Center

Phase

N/A

Condition

Dementia

Memory Loss

Memory Problems

Treatment

N/A

Clinical Study ID

NCT01421420

P30AG019610

Ages > 50
All Genders
Accepts Healthy Volunteers

Study Summary

The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening.

All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Eligibility Criteria

Inclusion

Inclusion Criteria: For patients with MCI, or dementia, the presence of cognitive deficits including memory,language, and executive function.

Exclusion

Exclusion Criteria: Presence of non-neurological medical conditions interfering with cognition.

Study Design

July 01, 2001

July 31, 2025

Study Description

All participants are seen annually. In addition to a detailed neurological examination, participants will receive a standardized battery of neuropsychological tests and will undergo genetic testing. The investigators will provide standardized periodic longitudinal assessment of the research participants. Autopsies to establish neurohistopathological diagnoses in clinically well-characterized patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Connect with a study center

University of Arizona, University Medical Center
Tucson, Arizona 85724
United States
Active - Recruiting

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