Observational Study for Left Main Disease Treatment

Last updated: March 18, 2026
Sponsor: Seung-Jung Park
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vascular Diseases

Cardiovascular Disease

Atherosclerosis

Treatment

N/A

Clinical Study ID

NCT01341327
CVRF2010-08
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to observe clinical courses for long-term in patients with unprotected LMCA disease and to evaluate comparative results of medical treatment, coronary stenting with drug-eluting stents, and CABG for the treatment of an unprotected LMCA stenosis in the "real world" daily practice.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Significant unprotected left main stenosis (>50% by visual estimation)

  • The LMCA is considered unprotected if there are no patent coronary arterybypass grafts to the left anterior descending artery or the left circumflexartery.

  • No limitation of clinical or lesion characteristics

  • Age >18 years

  • The patient or guardian agrees to the study protocol and the schedule of clinicalfollow-up, and provides informed, written consent, as approved by the appropriateInstitutional Review Board/Ethics Committee of the respective clinical site.

Exclusion

Exclusion Criteria:

  • Protected left main stenosis

Study Design

Total Participants: 10000
Study Start date:
July 01, 2007
Estimated Completion Date:
December 31, 2033

Study Description

This study is a multicenter, large clinical registry to evaluate comparative outcomes of medical therapy, PCI with DES, or CABG for patients with unprotected LMCA stenosis in the Asia-Pacific, as recorded in the MAIN-IRIS Registry. Data will be prospectively collected on approximately 5000 subjects who diagnosed LM disease (>50% by visual estimation) at approximately 65 centers in Korea and Asia-Pacific region. Brief study design is as depicted in the following figure

Connect with a study center

  • Zhongshan Hospital

    Shanghai,
    China

    Active - Recruiting

  • Hallym University medical center

    Anyang,
    Korea, Republic of

    Active - Recruiting

  • Soonchunhyang University Hospital, Buchen

    Bucheon,
    Korea, Republic of

    Site Not Available

  • The Catholic University of Korea, Bucheon ST.Mary's Hospital

    Bucheon,
    Korea, Republic of

    Terminated

  • Inje University Busan Paik Hospital

    Busan,
    Korea, Republic of

    Active - Recruiting

  • Soonchunhyang University Hospital, Cheonan

    Cheonan,
    Korea, Republic of

    Active - Recruiting

  • St.Mary's Catholic Medical Center

    Cheongju,
    Korea, Republic of

    Site Not Available

  • Daegu Catholic University Medical Center

    Daegu,
    Korea, Republic of

    Active - Recruiting

  • Keimyung University Dongsan Medical Center

    Daegu,
    Korea, Republic of

    Active - Recruiting

  • Yeungnam University Medical Center

    Daegu,
    Korea, Republic of

    Terminated

  • Chungnam National University Hospital

    Daejeon,
    Korea, Republic of

    Active - Recruiting

  • The Catholic University of Korea, Daejeon ST.Mary's Hospital

    Daejeon,
    Korea, Republic of

    Terminated

  • Gangneung Asan Medical Center

    Gangneung,
    Korea, Republic of

    Active - Recruiting

  • Chonnam National University Hospital

    Gwangju,
    Korea, Republic of

    Active - Recruiting

  • National Health Insurance Service Ilsan Hospital

    Ilsan,
    Korea, Republic of

    Terminated

  • St.Mary's Catholic Medical Center

    Inchon,
    Korea, Republic of

    Terminated

  • Chonbuk National University Hospital

    Jeonju,
    Korea, Republic of

    Active - Recruiting

  • Presbyterian Medical Center

    Jeonju,
    Korea, Republic of

    Active - Recruiting

  • Kwangju Christian hospital

    Kwangju,
    Korea, Republic of

    Active - Recruiting

  • Pusan Natioanal University Hospital

    Pusan,
    Korea, Republic of

    Active - Recruiting

  • Bundang CHA Hospital

    Seongnam,
    Korea, Republic of

    Terminated

  • Asan Medical Center

    Seoul, 138-736
    Korea, Republic of

    Active - Recruiting

  • Dongguk University Medical Center

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Gangnam Severance Hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Kangbuk samsung hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Kangdong Sacred Heart Hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Korea University Anam hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Korea University Guro Hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Seoul National University Boramae Medical Center

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Seoul National University Hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Seoul Veterans Hospital

    Seoul,
    Korea, Republic of

    Terminated

  • St.Mary's Catholic Medical Center

    Seoul,
    Korea, Republic of

    Terminated

  • The Catholic University of Korea, ST. Paul's Hospital

    Seoul,
    Korea, Republic of

    Terminated

  • The Catholic University of Korea, Yeouido ST. Mary's Hospital

    Seoul,
    Korea, Republic of

    Terminated

  • Yonsei University Medical Center

    Seoul,
    Korea, Republic of

    Terminated

  • Ajou University Hospital

    Suwon,
    Korea, Republic of

    Terminated

  • The Catholic University of Korea, ST. Vincent's Hospital

    Suwon,
    Korea, Republic of

    Active - Recruiting

  • Ulsan University Hospital

    Ulsan,
    Korea, Republic of

    Active - Recruiting

  • Wonju Christian Hospital

    Wonju,
    Korea, Republic of

    Site Not Available

  • Sarawak General Hospital

    Kuching,
    Malaysia

    Active - Recruiting

  • Hallym University medical center

    Anyang,
    South Korea

    Active - Recruiting

  • Soonchunhyang University Hospital, Buchen

    Bucheon-si,
    South Korea

    Terminated

  • The Catholic University of Korea, Bucheon ST.Mary's Hospital

    Bucheon-si,
    South Korea

    Terminated

  • Inje University Busan Paik Hospital

    Busan,
    South Korea

    Active - Recruiting

  • Soonchunhyang University Hospital, Cheonan

    Cheonan,
    South Korea

    Active - Recruiting

  • St.Mary's Catholic Medical Center

    Cheongju-si,
    South Korea

    Terminated

  • Daegu Catholic University Medical Center

    Daegu,
    South Korea

    Active - Recruiting

  • Keimyung University Dongsan Medical Center

    Daegu,
    South Korea

    Active - Recruiting

  • Yeungnam University Medical Center

    Daegu,
    South Korea

    Terminated

  • Chungnam National University Hospital

    Daejeon,
    South Korea

    Active - Recruiting

  • The Catholic University of Korea, Daejeon ST.Mary's Hospital

    Daejeon,
    South Korea

    Terminated

  • Gangneung Asan Medical Center

    Gangneung,
    South Korea

    Active - Recruiting

  • Chonnam National University Hospital

    Gwangju,
    South Korea

    Active - Recruiting

  • National Health Insurance Service Ilsan Hospital

    Ilsan,
    South Korea

    Terminated

  • St.Mary's Catholic Medical Center

    Inchon,
    South Korea

    Terminated

  • Chonbuk National University Hospital

    Jeonju,
    South Korea

    Active - Recruiting

  • Presbyterian Medical Center

    Jeonju,
    South Korea

    Active - Recruiting

  • Kwangju Christian hospital

    Kwangju,
    South Korea

    Active - Recruiting

  • Pusan Natioanal University Hospital

    Pusan,
    South Korea

    Active - Recruiting

  • Bundang CHA Hospital

    Seongnam,
    South Korea

    Terminated

  • Asan Medical Center

    Seoul, 138-736
    South Korea

    Active - Recruiting

  • Dongguk University Medical Center

    Seoul,
    South Korea

    Active - Recruiting

  • Gangnam Severance Hospital

    Seoul,
    South Korea

    Active - Recruiting

  • Kangbuk samsung hospital

    Seoul,
    South Korea

    Active - Recruiting

  • Kangdong Sacred Heart Hospital

    Seoul,
    South Korea

    Active - Recruiting

  • Korea University Anam hospital

    Seoul,
    South Korea

    Active - Recruiting

  • Korea University Guro Hospital

    Seoul,
    South Korea

    Active - Recruiting

  • Seoul National University Boramae Medical Center

    Seoul,
    South Korea

    Active - Recruiting

  • Seoul National University Hospital

    Seoul,
    South Korea

    Active - Recruiting

  • Seoul Veterans Hospital

    Seoul,
    South Korea

    Terminated

  • St.Mary's Catholic Medical Center

    Seoul,
    South Korea

    Terminated

  • The Catholic University of Korea, ST. Paul's Hospital

    Seoul,
    South Korea

    Terminated

  • The Catholic University of Korea, Yeouido ST. Mary's Hospital

    Seoul,
    South Korea

    Terminated

  • Yonsei University Medical Center

    Seoul,
    South Korea

    Terminated

  • Ajou University Hospital

    Suwon,
    South Korea

    Terminated

  • The Catholic University of Korea, ST. Vincent's Hospital

    Suwon,
    South Korea

    Active - Recruiting

  • Ulsan University Hospital

    Ulsan,
    South Korea

    Active - Recruiting

  • Wonju Christian Hospital

    Wŏnju,
    South Korea

    Active - Recruiting

  • Shin Kong Hospital

    Taipei,
    Taiwan

    Active - Recruiting

  • Siriraj Hospital

    Bangkok,
    Thailand

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.