Abatacept Versus Adalimumab Head-to-Head

Inclusion Criteria:

• Moderate to severe Rheumatoid arthritis (RA) according to American College ofRheumatology (ACR) criteria

• Methotrexate failure

• Naive to RA biologics

• ≤5 years duration of disease

• Disease Activity Score-28 C-reactive protein (DAS28 CRP) ≥ 3.2

• Willingness to self-inject subcutaneous (SC) drug

Exclusion Criteria:

• Previous or current medical conditions that are warnings against the use of tumornecrosis factor (TNF)-blocking agents

• History of active or chronic hepatitis

• Cancer in the last 5 years

• History of severe chronic or recurrent bacterial or viral infections

• Risk of tuberculosis

• Current symptoms of severe, progressive, or uncontrolled renal, hepatic, hematologic,Gastro-intestinal, pulmonary, cardiac, neurologic, or cerebral disease