Mechanisms Underlying Impaired Diabetic Wound Healing

Last updated: September 4, 2024
Sponsor: University of Pittsburgh
Overall Status: Active - Recruiting

Phase

N/A

Condition

Diabetic Macular Edema

Diabetic Foot Ulcers

Diabetic Vitreous Hemorrhage

Treatment

Blood draw

Clinical Study ID

NCT00777712
STUDY23070132
  • Ages 21-80
  • All Genders

Study Summary

The overall aim of this research is to utilize wound derived inflammatory cells from diabetic versus non diabetic human chronic wounds to understand mechanisms that are responsible for disregulated inflammation in individuals with diabetes. Biology of normal (peripheral blood derived cells) versus wound derived cells will also be studied.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Ages 21-80

  • Chronic Wound (present >4 weeks)

  • Diabetic & Non-diabetic

  • Adult surgical wounds

Exclusion

Exclusion Criteria:

  • Inability to consent

  • Pregnant women

  • Therapeutically immunocompromised

  • Individuals defined in 45 CFR 46 Subparts B,C, and D, nor from any other populationconsidered vulnerable 2.9

Study Design

Total Participants: 250
Treatment Group(s): 1
Primary Treatment: Blood draw
Phase:
Study Start date:
September 01, 2008
Estimated Completion Date:
December 31, 2030

Study Description

Specific aims:

  1. To study biology of wound derived inflammatory cells and fluid from diabetic versus non diabetic wounds.

  2. To characterize mechanisms that are responsible for dysregulated wound inflammatory cell function in individuals with diabetes.

  3. To characterize differences in the biology of normal peripheral blood derived cells versus wound derived cells.

The long-term goal of this study is to determine the molecular mechanisms underlying impaired wound healing in diabetics.

Connect with a study center

  • Comprehensive Wound Care Centers

    Indianapolis, Indiana 46202
    United States

    Completed

  • Comprehensive Wound Care Centers

    Columbus, Ohio 43210
    United States

    Completed

  • University of Pittsburgh - McKeesport

    Pittsburgh, Pennsylvania 15132
    United States

    Active - Recruiting

  • University of Pittsburgh - Mercy

    Pittsburgh, Pennsylvania 15219
    United States

    Active - Recruiting

  • University of Pittsburgh - Passavant

    Pittsburgh, Pennsylvania 16066
    United States

    Active - Recruiting

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