Phase
Condition
Thrombocytopenia And Thrombocytopenia Prevention
Kidney Failure (Pediatric)
Nephritis
Treatment
N/AClinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- any patient 18 years or older diagnosed with relapsed or refractory TTP-HUS requiringtherapy
Exclusion
Exclusion Criteria:
alternate cause of hemolytic microangiopathy (evidence of DIC, malignant hypertension,vasculitis, anti-phospholipid antibody syndrome, post-partum acute renal failure)
congenital or familial TTP
TTP occuring post-stem cell, bone marrow, or solid organ transplant
drug-induced TTP
pregnancy or breast-feeding
history of hepatitis B or C infection
prior rituximab treatment
active or metastatic cancer
other causes of thrombocytopenia such as ITP, myelodysplastic syndrome, confirmed orsuspected drug-induced thrombocytopenia
refusal to receive blood products
hypersensitivity to blood products, plasma products, murine proteins, or any componentof the Rituximab formulation
geographic inaccessibility
co-morbid illness limiting life expectancy to less than 2 months independent of TTP
failure to provide written informed consent
Study Design
Connect with a study center
Foothills Medical Centre, Calgary Health REgion Apheresis Service
Calgary, Alberta T2N 2T9
CanadaSite Not Available
University of Alberta Hospital
Edmonton, Alberta
CanadaSite Not Available
Vancouver General Hospital
Vancouver, British Columbia V5Z1M9
CanadaActive - Recruiting
Winnipeg Regional Health Authority, Apheresis Department
Winnipeg, Manitoba R3E 0T2
CanadaSite Not Available
St. John Regional Hospital
St. John, New Brunswick E2K5S9
CanadaSite Not Available
Hamilton Health Sciences
Hamilton, Ontario L8N 3Z5
CanadaActive - Recruiting
London Health Sciences Centre, Westminister Campus
London, Ontario N6A4G5
CanadaActive - Recruiting
Princess Margaret Hospital, ABMT/Apheresis Unit
Toronto, Ontario M5G2M9
CanadaActive - Recruiting
Hopital Charles Lemoyne
Greenfield Park, Quebec
CanadaSite Not Available
Hopital du Sacre-Coeur de Montreal
Montreal, Quebec H4J1C5
CanadaSite Not Available
St. Paul's Hospital Apheresis Unit
Saskatoon, Saskatchewan S7M 0Z9
CanadaActive - Recruiting
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