Imaging Techniques for Identifying Factors of Sudden Cardiac Death Risk

Last updated: January 9, 2025
Sponsor: Johns Hopkins University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Disease

Heart Defect

Cardiac Ischemia

Treatment

N/A

Clinical Study ID

NCT00181233
NA_00037404
  • Ages > 18
  • All Genders

Study Summary

Sudden cardiac death is a tragic event that strikes all age groups and is unfortunately increasing in prevalence. Because it is difficult to predict those at highest risk, this study is designed to test the hypothesis that new imaging techniques (magnetic resonance imaging [MRI] and computed tomography [CT]) are useful for identifying factors which put people at high risk for sudden death.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Left ventricular ejection fraction <or = 35%

  • Planned implantable cardioverter-defibrillator (ICD) implantation for clinicalindications (primary prevention)

Exclusion

Exclusion Criteria:

  • History of sudden death (secondary prevention)

  • Contraindication to undergoing MRI (metallic implant, pacemaker, etc.)

Study Design

Total Participants: 400
Study Start date:
October 01, 2003
Estimated Completion Date:
July 31, 2029

Study Description

Some people with heart disease and a weak heart muscle experience abnormal electrical activity of the heart that may predispose them to sudden death. In light of this risk, it has been recommended that such patients undergo implantation of an implantable cardioverter defibrillator (ICD). Your doctors have determined that you are such a patient and are to undergo implantation of an ICD. It is unclear who among the many patients who undergo ICD implantation for this reason are at greatest risk of sudden death and therefore require electrical response from their ICD. This research is being done to determine whether new imaging tests, such as magnetic resonance imaging (MRI) or multi-detector computed tomography (MDCT), can be used to predict who is at highest risk of sudden death and require electrical response from their ICD.

Connect with a study center

  • Johns Hopkins Medical Institutions

    Baltimore, Maryland 21287
    United States

    Active - Recruiting

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