Last updated on February 2019

Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction


Brief description of study

To determine whether treatment with sacubitril/valsartan provides a superior effect on aortic characteristic impedance compared to enalapril in patients with heart failure and reduced ejection fraction (left ventricular ejection fraction [LVEF] 40%) after 12 weeks of treatment. The primary endpoint is the change in aortic characteristic impedance (Zc = dP/dQ in early systole) between baseline and Week 12.

Clinical Study Identifier: NCT02874794

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Novartis Pharmaceuticals

Novartis Investigative Site
Rocky Mount, NC United States
5.83miles
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Recruitment Status: Open


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