Last updated on January 2019

Filling Bone Defects/Voids With Autologous BonoFill-II for Maxillofacial Bone Regeneration


Brief description of study

The purpose of this clinical study is to evaluate the safety and the efficacy of BonoFill-II as a bone filler containing the patient's own (autologous) adipose (fat) tissue-derived cells in reconstructing bone in two clinical indications:

  1. Bone augmentation (e.g. sinus augmentation)
  2. Bone grafting after removal of cysts from jaws

Detailed Study Description

Primary endpoint:

The transplantation of BonoFill-II to the maxillary or mandible defect/void is safe under the following conditions: No chronic bone infection (Osteomyelitis); no significant changes in complete blood count (CBC) and in general health.

Secondary endpoint:

The transplantation of BonoFill-II to the maxillary or mandible void is efficient under the following conditions: Following BonoFill-II implantation, the bone regeneration in the operated site was significantly accelerated. Also, the bone defects/voids were filled with a significant amount of bone tissue.

Clinical Study Identifier: NCT02842619

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Recruitment Status: Open


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