Last updated on May 2018

Fluid Responsiveness Evaluation in Sepsis-associated Hypotension

Brief description of study

This study assesses the mean difference in fluid balance at ICU discharge and associated patient outcomes, based on a dynamic assessment of fluid responsiveness in septic patients with refractory hypotension in an ICU setting.

Detailed Study Description

Multi-center randomized study comparing dynamic assessment of fluid responsiveness utilizing Starling SV monitor compared to a control group.

Subjects will be randomized in a 2:1 treatment to control group ratio to increase power for sub-analysis by patient population.

Patients randomized to the Starling SV arm will have treatment guided by a dynamic assessment of fluid responsiveness (measured by a change in stroke volume index > 10%) as assessed by passive leg raise (PLR).

Patients randomized to the control group will receive standard of care treatment.

Clinical Study Identifier: NCT02837731

Contact Investigators or Research Sites near you

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Ivor Douglas, MD

Denver Health
Denver, CO United States
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Philip Alapat, MD

Baylor College of Medicine
Houston, TX United States
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Recruitment Status: Open

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