Last updated on May 2019

A Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis (UC)


Brief description of study

This study comprises three sub-studies. The objective of sub-study 1 is to characterize the dose-response, efficacy, and safety of upadacitinib compared to placebo in inducing clinical remission in order to identify the induction dose of upadacitinib for further evaluation in sub-study 2. The objective of sub-study 2 is to evaluate the efficacy and safety of upadacitinib compared to placebo in inducing clinical remission in participants. The objective of sub-study 3 is to evaluate the efficacy and safety of upadacitinib compared to placebo in achieving clinical remission in participants who had a response following induction with upadacitinib.

Clinical Study Identifier: NCT02819635

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Facey Medical Foundation /ID# 203133

Mission Hills, CA United States
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Delta Waves, Inc. /ID# 151721

Colorado Springs, CO United States
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Gastro Florida /ID# 155245

Clearwater, FL United States
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Borland-Groover Clinic /ID# 170912

Jacksonville, FL United States
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SIH Research, LLC /ID# 163319

Kissimmee, FL United States
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Advanced Research Institute /ID# 163098

New Port Richey, FL United States
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Tri-State Gastroenterology /ID# 169811

Crestview Hills, KY United States
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NY Scientific /ID# 152707

Brooklyn, NY United States
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Premier Medical Group /ID# 153357

Poughkeepsie, NY United States
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Gastro One /ID# 151144

Germantown, TN United States
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Sagact Pllc /Id# 169396

San Antonio, TX United States
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University of Utah /ID# 152711

Salt Lake City, UT United States
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Utah Gastroenterology /ID# 163101

Salt Lake City, UT United States
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The Polyclinic /ID# 164369

Seattle, WA United States
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Gedyt /ID# 210015

Ciudad Autonoma Buenos Aires, Argentina
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Sanatorio 9 de Julio S.A. /ID# 150189

San Miguel de Tucuman, Argentina
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Crchum /Id# 167169

Montreal, QC Canada
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Hopital Saint Eloi /ID# 200006

Montpellier CEDEX 5, France
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CHD Vendee /ID# 154452

La Roche Sur Yon, France
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Hopital Nord /ID# 154453

Saint Priest En Jarez, France
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Hospital Ampang /ID# 151298

Ampang, Selangor, Malaysia
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LLC Uromed /ID# 200724

Smolensk, Russian Federation
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LLC Novaya Klinika /ID# 208107

Pyatigorsk, Russian Federation
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PMI Euromedservice /ID# 203800

Pushkin, Russian Federation
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Mediclinic Milnerton /ID# 162202

CAPE TOWN,Milnerton, South Africa
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MD Search /ID# 167293

Boksburg North, South Africa
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Hospital Univ Dr. Negrin /ID# 203937

Las Palmas de Gran Canaria, Spain
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