Last updated on June 2020

Phase Ib/II Study of MCS110 in Combination With PDR001 in Patients With Advanced Malignancies

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Peripheral Arterial Occlusive Disease | Islet Ce417ll Cancer | Pediatric Health | Brain Function | Chronic Shoulder Pain | Drugs | Pancreatic Cancer | Breast Cancer - HER2 Positive | Triple Negative Breast Cancer | Endometrial Cancer | Uterine Cancer | Breast Cancer | Diet and Nutrition | Chronic Diarrhea | Anal Dysplasia | Vaginal Atrophy | Metastatic Triple-Negative Breast Cancer | Malignant Melanoma | Injection Port | melanoma | Skin Wounds | Razor Bumps (Pseudofolliculitis Barbae) | Near-Sighted Corrective Surgery | Primary Immunodeficiency | Metastatic Melanoma | Recurrent Respiratory Papillomatosis | Endometrial Carcinoma | skin cancer | Adverse Effects
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Signed informed consent prior to any procedures
  • Patients with advanced melanoma, endometrial carcinoma, pancreatic or TNBC, with measurable or non-measurable disease who have progressed despite standard therapy or are intolerant of standard therapy, or for whom no standard therapy exists.

Exclusion Criteria:

  • Patient having out of range laboratory values defined as:
  • Creatinine clearance < 40 mL/min
  • Total bilirubin > 1.5 x ULN
  • Absolute neutrophil count < 1.0 x 109/L
  • Hemoglobin (Hgb) < 9 g/dL
  • Impaired cardiac function or clinically significant cardiac disease
  • Active autoimmune disease
  • Malignant disease, other than that being treated in this study.
  • Presence of CTCAE Grade 2 toxicity due to prior cancer therapy.
  • Pregnant or lactating women

Other protocol-defined inclusion/exclusion may apply.

Recruitment Status: Closed

Brief Description Eligibility Contact Research Team

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