Last updated on January 2019

Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosis.


Brief description of study

To compare the efficacy and safety of ofatumumab administered subcutaneously (sc) every 4 weeks versus teriflunomide administered orally once daily in patients with relapsing multiple sclerosis

Detailed Study Description

This is a randomized, double-blind, double-dummy, active comparator-controlled, parallel-group, multicenter study with variable treatment duration in approximately 900 patients with relapsing MS. The maximal treatment duration in the study for an individual patient will be 2.5 years.

Eligible patients will be randomized to receive either experimental ofatumumab subcutaneous (sc) injections every 4 weeks or active comparator teriflunomide orally once daily. In order to blind for the different formulations, double-dummy masking will be used i.e. all patients will take injections (containing either active ofatumumab or placebo) and oral capsules (containing either active teriflunomide or placebo).

Clinical Study Identifier: NCT02792231

Find a site near you

Start Over

Novartis Investigative Site

Birmingham, AL United States
  Connect »

Novartis Investigative Site

Cullman, AL United States
  Connect »

Novartis Investigative Site

Phoenix, AZ United States
  Connect »

Novartis Investigative Site

Boulder, CO United States
  Connect »

Novartis Investigative Site

Centennial, CO United States
  Connect »

Novartis Investigative Site

Colorado Springs, CO United States
  Connect »

Novartis Investigative Site

Fort Collins, CO United States
  Connect »

Novartis Investigative Site

Fairfield, CT United States
  Connect »

Novartis Investigative Site

Bradenton, FL United States
  Connect »

Novartis Investigative Site

Maitland, FL United States
  Connect »

Novartis Investigative Site

Oldsmar, FL United States
  Connect »

Novartis Investigative Site

Orlando, FL United States
  Connect »

Novartis Investigative Site

Ormond Beach, FL United States
  Connect »

Novartis Investigative Site

Palm Coast, FL United States
  Connect »

Novartis Investigative Site

Saint Petersburg, FL United States
  Connect »

Novartis Investigative Site

Sarasota, FL United States
  Connect »

Novartis Investigative Site

Tallahassee, FL United States
  Connect »

Novartis Investigative Site

Atlanta, GA United States
  Connect »

Novartis Investigative Site

Columbus, GA United States
  Connect »

Novartis Investigative Site

Suwanee, GA United States
  Connect »

Novartis Investigative Site

Flossmoor, IL United States
  Connect »

Novartis Investigative Site

Anderson, IN United States
  Connect »

Novartis Investigative Site

Indianapolis, IN United States
  Connect »

Novartis Investigative Site

Louisville, KY United States
  Connect »

Novartis Investigative Site

Baltimore, MD United States
  Connect »

Novartis Investigative Site

Lexington, MA United States
  Connect »

Novartis Investigative Site

Worcester, MA United States
  Connect »

Novartis Investigative Site

Detroit, MI United States
  Connect »

Novartis Investigative Site

Farmington Hills, MI United States
  Connect »

Novartis Investigative Site

Grand Rapids, MI United States
  Connect »

Novartis Investigative Site

Golden Valley, MN United States
  Connect »

Novartis Investigative Site

Great Falls, MT United States
  Connect »

Novartis Investigative Site

Freehold, NJ United States
  Connect »

Novartis Investigative Site

Albuquerque, NM United States
  Connect »

Novartis Investigative Site

Plainview, NY United States
  Connect »

Novartis Investigative Site

Asheville, NC United States
  Connect »

Novartis Investigative Site

Charlotte, NC United States
  Connect »

Novartis Investigative Site

Greensboro, NC United States
  Connect »

Novartis Investigative Site

Hendersonville, NC United States
  Connect »

Novartis Investigative Site

Uniontown, OH United States
  Connect »

Novartis Investigative Site

Portland, OR United States
  Connect »

Novartis Investigative Site

Springfield, OR United States
  Connect »

Novartis Investigative Site

Hershey, PA United States
  Connect »

Novartis Investigative Site

Philadelphia, PA United States
  Connect »

Novartis Investigative Site

Pittsburgh, PA United States
  Connect »

Novartis Investigative Site

Willow Grove, PA United States
  Connect »

Novartis Investigative Site

Knoxville, TN United States
  Connect »

Novartis Investigative Site

Nashville, TN United States
  Connect »

Novartis Investigative Site

Greenville, TX United States
  Connect »

Novartis Investigative Site

Lubbock, TX United States
  Connect »

Novartis Investigative Site

Sherman, TX United States
  Connect »

Novartis Investigative Site

Salt Lake City, UT United States
  Connect »

Novartis Investigative Site

Kirkland, WA United States
  Connect »

Novartis Investigative Site

Seattle, WA United States
  Connect »

Novartis Investigative Site

Waukesha, WI United States
  Connect »

Novartis Investigative Site

Greenfield Park, QC Canada
  Connect »

Novartis Investigative Site

Santa Maria Da Feira, Portugal
  Connect »

Novartis Investigative Site

Ekaterinburg, Russian Federation
  Connect »

Novartis Investigative Site

Kazan, Russian Federation
  Connect »

Novartis Investigative Site

Krasnoyarsk, Russian Federation
  Connect »

Novartis Investigative Site

Moscow, Russian Federation
  Connect »

Novartis Investigative Site

Nizhny Novgorod, Russian Federation
  Connect »

Novartis Investigative Site

Novosibirsk, Russian Federation
  Connect »

Novartis Investigative Site

St. Petersburg, Russian Federation
  Connect »

Novartis Investigative Site

Pozuelo de Alarcon, Spain
  Connect »

Novartis Investigative Site

Haseki / Istanbul, Turkey
  Connect »

Novartis Investigative Site

Sheffield, United Kingdom
  Connect »

Novartis Investigative Site

Chicago, IL United States
  Connect »

Novartis Investigative Site

Foxboro, MA United States
  Connect »

Novartis Investigative Site

Lebanon, NH United States
  Connect »

Novartis Investigative Site

Cordova, TN United States
  Connect »

Novartis Investigative Site

Newcastle Upon Tyne, United Kingdom
  Connect »

Novartis Investigative Site

Gainesville, FL United States
  Connect »

Novartis Investigative Site

Billings Montana, MT United States
  Connect »

Novartis Investigative Site

Westerville, OH United States
  Connect »

Novartis Investigative Site

Wellesley, MA United States
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.