Last updated on December 2018

Multicenter Automatic Defibrillator Implantation Trial With Subcutaneous Implantable Cardioverter Defibrillator

Brief description of study

The MADIT S-ICD trial is designed to evaluate if subjects with a prior myocardial infarction, diabetes mellitus and a relatively preserved ejection fraction of 36-50% will have a survival benefit from receiving a subcutaneous implantable cardioverter defibrillator (S-ICD) when compared to those receiving conventional medical therapy.

Detailed Study Description

In this study, subjects will be randomized to receive a subcutaneous implantable cardioverter defibrillator or Conventional Medical Therapy (CMT). Randomization will be stratified by enrolling site, in a 2:1 (S-ICD:CMT) scheme. Length of follow-up for each subject will be dependent on the date of entry into the study, since all subjects will be followed to a common study termination date.

Clinical Study Identifier: NCT02787785

Contact Investigators or Research Sites near you

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Heart Center Research, LLC.

Huntsville, AL United States

Huntington Hospital

Pasadena, CA United States

Emory University

Atlanta, GA United States

University of Iowa

Iowa City, IA United States

University of Louisville

Louisville, KY United States

Henry Ford Hospital

Detroit, MI United States

Nebraska Heart Institute

Lincoln, NE United States

Ohio State Wexner Medical Center

Columbus, OH United States

Promedica Toledo Hospital

Toledo, OH United States

Phoenixville Hospital

Phoenixville, PA United States

University of Texas, Houston

Houston, TX United States

Sentara Norfolk General

Norfolk, VA United States

University of Southern California

Los Angeles, CA United States

Alta Bates Summit Hospital

Oakland, CA United States

Advanced Cardiovascular Specialists

Shreveport, LA United States

Saint Luke's Hospital

Kansas City, MO United States

Catholic Medical Center

Manchester, NH United States

Northwell Health

Manhasset, NY United States

North Carolina Heart and Vascular

Raleigh, NC United States

Ohio Health Research Institute

Columbus, OH United States

Erlanger Medical Center

Chattanooga, TN United States

UMC Utrecht

Utrecht, Netherlands

Academisch Medisch Centrum

Amsterdam, Netherlands

Loyola University Medical Center

Maywood, IL United States

Cardiovascular Associates of Delaware Valley

Haddon Heights, NJ United States

Abington Memorial Hospital

Abington, PA United States

Virginia Commonwealth University

Richmond, VA United States

University of Washington

Seattle, WA United States

PeaceHealth Southwest Medical Center

Vancouver, WA United States

Unfallkrankenhaus Berlin

Berlin, Germany

Kaplan Medical Center

Rechovot, Israel

Mayo Clinic- Scottsdale

Scottsdale, AZ United States

Glendale Adventist Medical Center

Glendale, CA United States

St. Bernard's Medical Center

Jonesboro, AR United States

Tufts Medical Center

Boston, MA United States

University Hospital Zurich

Zürich, Switzerland

Recruitment Status: Closed

Brief Description Eligibility Contact Research Team

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