Last updated on December 2018

Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ) Compared to Placebo in Subjects With Rheumatoid Arthritis (RA) Who Are Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Have Active Disease


Brief description of study

The purpose of this study is to determine how safe and effective the study drug Olokizumab is, in patients with Rheumatoid Arthritis (RA) who are already receiving, but not fully responding to treatment with an existing medication called a tumour necrosis factor alpha inhibitor

Detailed Study Description

The goal of this Phase III study is to assess the safety, tolerability, and efficacy of OKZ in subjects with moderately to severely active RA who have responded inadequately to TNFi therapy. The primary endpoint of the trial is at Week 12. Olokizumab is expected to reduce the disease activity and improve physical function. The study is expected to provide safety information in a large group of subjects over at least a 24 week period.

Clinical Study Identifier: NCT02760433

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CHI St. Vincent Hot Springs

Hot Springs, AR United States
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Little Rock Diagnostic Clinic, PA

Little Rock, AR United States
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MD Med Corp.

Hemet, CA United States
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Riverside Medical Clinic

Riverside, CA United States
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Denver Arthritis Clinic

Denver, CO United States
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RASF - Clinical Research Center

Boca Raton, FL United States
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Suncoast Research

Miami, FL United States
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Family Clinical Trials, LLC.

Pembroke Pines, FL United States
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Institute of Arthritis Research

Idaho Falls, ID United States
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Graves Gilbert Clinic

Bowling Green, KY United States
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Research Integrity, LLC.

Owensboro, KY United States
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Center for Rheumatology

Albany, NY United States
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Medication Management, LLC

Greensboro, NC United States
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Carolina Arthritis Associates

Wilmington, NC United States
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STAT Research, Inc.

Dayton, OH United States
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Clinical Research Source, Inc.

Perrysburg, OH United States
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Arthritis Group

Philadelphia, PA United States
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Low Country Research Center

Charleston, SC United States
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Sanatorio Delta

Rosario, Argentina
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Sanatorio San Martin

Venado Tuerto, Argentina
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Centro Medico Privado de Reumatologia

San Miguel de Tucuman, Argentina
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Organizacion Medica de Investigacion (OMI)

Ciudad Autonoma Buenos Aires, Argentina
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APRILLUS

Ciudad Autonoma Buenos aires, Argentina
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Instituto Centenario

Ciudad Autonoma Buenos Aires, Argentina
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Hospital General de Agudos Dr. J. M. Ramos Mejia

Ciudad Autonoma Buenos Aires, Argentina
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Atencion Integral en Reumatologia (AIR)

Ciudad Autonoma Buenos Aires, Argentina
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Medicity S.A.S.

Bucaramanga, Colombia
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Revmatologie MUDr. Klara Sirova s.r.o.

Ostrava - Moravska Ostrava, Czechia
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MEDICAL PLUS s.r.o.

Uherske Hradiste, Czechia
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SMO.MD GmbH

Magdeburg, Germany
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Ajou University Hospital

Suwon-si, Korea, Republic of
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Eulji University Hospital

Daejeon, Korea, Republic of
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McBk S.C.

Grodzisk Mazowiecki, Poland
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Medvin Clinical Research

Covina, CA United States
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Omega Research Consultants

Orlando, FL United States
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Advanced Clinical Research

Meridian, ID United States
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The Rheumatology Group PLLC

South Charleston, WV United States
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Cape Fear Arthritis Care

Leland, NC United States
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Medvin Clinical Research

Whittier, CA United States
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Arthritis Center of North Georgia

Gainesville, GA United States
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Trinity Medical Group

Minot, ND United States
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Recruitment Status: Open


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