Last updated on January 2019

A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer


Brief description of study

This is an international multi-center, prospective, open-label, randomized, adaptive design phase 3 trial of the cancer stem cell pathway inhibitor napabucasin plus standard bi-weekly FOLFIRI versus standard bi-weekly FOLFIRI in patients with previously treated metastatic colorectal cancer (CRC).

Clinical Study Identifier: NCT02753127

Contact Investigators or Research Sites near you

Start Over

Boston Biomedical

Alabama Oncology
Birmingham, AL United States
  Connect »

Laurie Mihalik

Mayo Clinic Arizona
Phoenix, AZ United States
  Connect »

Megan Kirkwood

Arizona Oncology Associates, PC - HOPE
Tucson, AZ United States
  Connect »

Sudha Dara

Comprehensive Blood and Cancer Center
Bakersfield, CA United States
  Connect »

Heera Pokhrel

City of Hope- Comprehensive Care Center
Duarte, CA United States
  Connect »

Erika Buell

University of California-San Diego/Moores UCSD Cancer Center
La Jolla, CA United States
  Connect »

Boston Biomedical

Los Angeles Hematology Oncology Medical Group
Los Angeles, CA United States
  Connect »

Maria Garcia Leiva

USC Norris Comprehensive Cancer Center
Los Angeles, CA United States
  Connect »

Robin Kemball

UCLA Hematology Oncology Santa Monica
Santa Monica, CA United States
  Connect »

Kimberly Young

St. Joseph Heritage Healthcare
Santa Rosa, CA United States
  Connect »

Megan Kirkwood

Rocky Mountain Cancer Centers
Denver, CO United States
  Connect »

Boston Biomedical

St Mary's Hospital & Regional Med Center
Grand Junction, CO United States
  Connect »

Kathleen Combs

Medical Oncology Hematology Consultants, PA
Newark, DE United States
  Connect »

Dawn Andrews

Florida Cancer Specialists & Research Institute Fort Myers
Fort Myers, FL United States
  Connect »

Mihaela Roldan

Memorial Cancer Institute at Memorial Hospital
Hollywood, FL United States
  Connect »

Carolina Manchola-Orozco

Baptist Health Medical Group Oncology, LLC
Miami, FL United States
  Connect »

Dinah Barnes

Sarah Cannon Research Institution
Saint Petersburg, FL United States
  Connect »

Jennifer Bar-Nur

Palm Beach Cancer Institute
West Palm Beach, FL United States
  Connect »

Ann Johnston

Piedmont Cancer Institute, PC
Atlanta, GA United States
  Connect »

Meredith Renfroe

Emory University/Winship Cancer Institute
Atlanta, GA United States
  Connect »

Shaneka Douglas

Suburban Hematology-Oncology Associates, PC - Lawrenceville
Lawrenceville, GA United States
  Connect »

Megan Kirkwood

Illinois Cancer Specialists
Arlington Heights, IL United States
  Connect »

Robert March

Northshore University Healthsystem
Evanston, IL United States
  Connect »

Mina Boyadzhieva

Healthcare Research Network III, LLC
Tinley Park, IL United States
  Connect »

Claudine Gamster

Northwestern Medicine Cancer Center
Warrenville, IL United States
  Connect »

Abby Reed

Parkview Research Center
Fort Wayne, IN United States
  Connect »

Vanessa DePue

Indiana University Health Goshen Center for Cancer Care
Goshen, IN United States
  Connect »

Lori Wiseman

Michiana Hematology Oncology, PC
Mishawaka, IN United States
  Connect »

Statesn Davis

Cancer Center of Kansas
Wichita, KS United States
  Connect »

Samantha Schuetz

Dana Farber
Boston, MA United States
  Connect »

Alexandra Agrillo

Umass Memorial Medical Center
Worcester, MA United States
  Connect »

Patricia Bebee

University of Michigan Cancer Center
Ann Arbor, MI United States
  Connect »

Megan Kirkwood

Minnesota Oncology Hematology, P.A.
Minneapolis, MN United States
  Connect »

Lori Heinrichs

Mayo Clinic Arizona
Rochester, MN United States
  Connect »

Zac Clifford

Research Medical Center
Kansas City, MO United States
  Connect »

Henry Robinson

Missouri Baptist Medical Center ACCRU Network Site
Saint Louis, MO United States
  Connect »

Mehmet Sitki Copur, MD

Saint Francis Cancer Treatment Center
Grand Island, NE United States
  Connect »

Mary Wilwerding

Missouri Valley Cancer Consortium
Omaha, NE United States
  Connect »

Boston Biomedical

Cancer Research Network of Nebraska / Oncology Associates PC
Omaha, NE United States
  Connect »

Melissa Daly

Tennessee Oncology PLLC
Omaha, NE United States
  Connect »

Susan Tarczewski

Darthmouth-Hitchcock Medical Center
Lebanon, NH United States
  Connect »

Michelle Mackenzie

Carol G. Simon Cancer Center
Morristown, NJ United States
  Connect »

Denise Buchanan

University of New Mexico
Albuquerque, NM United States
  Connect »

Suman Sarker

Roswell Park Cancer Center
Buffalo, NY United States
  Connect »

Don Marx

North Shore Hematology Oncology Associates
East Setauket, NY United States
  Connect »

Tong Dai

Weill Cornell Medical College
New York, NY United States
  Connect »

Sharon Grantham

Southeastern Medical Oncology Center
Goldsboro, NC United States
  Connect »

Laura Gilliam

Wake Forest Baptist Medical Center
Winston-Salem, NC United States
  Connect »

Pam Shoup

Toledo Clinic Cancer Centers
Toledo, OH United States
  Connect »

Heather Snyder

Geisinger Medical Center
Danville, PA United States
  Connect »

Sharlene Wylie

VA Pittsburgh Healthcare System
Pittsburgh, PA United States
  Connect »

Boston Biomedical

Medical University of South Carolina
Charleston, SC United States
  Connect »

Catherine Olson

Sanford Cancer Center
Sioux Falls, SD United States
  Connect »

Brandy Herbert

University of Tennessee Medical Center
Knoxville, TN United States
  Connect »

Ghazala Mazhar, MD

West Cancer Center
Memphis, TN United States
  Connect »

Scott Marx

The Sarah Cannon Research Institute
Nashville, TN United States
  Connect »

Megan Kirkwood

Texas Oncology-Austin Midtown
Austin, TX United States
  Connect »

Debora Jimerson

Texas Oncology - Dallas Center
Dallas, TX United States
  Connect »

Megan Kirkwood

Texas Oncology - Denton South
Denton, TX United States
  Connect »

Megan Kirkwood

Texas Oncology - Fort Worth
Fort Worth, TX United States
  Connect »

John Waldron

Millenium Oncology
Houston, TX United States
  Connect »

Suzette Clark

Texas Health Physicians Group
Plano, TX United States
  Connect »

Megan Kirkwood

Texas Oncology-San Antonio
San Antonio, TX United States
  Connect »

Megan Kirkwood

Texas Oncology - Tyler
Tyler, TX United States
  Connect »

Megan Kirkwood

Texas Oncology - Wichita Falls Texoma Cancer Center
Wichita Falls, TX United States
  Connect »

Shirley Waters

Northern Utah Associates
Ogden, UT United States
  Connect »

Karin Choquette

US Oncology - Virginia Cancer Specialists, PC
Fairfax, VA United States
  Connect »

Greneisha T Jackson

Fort Belvoir Community Hospital
Fort Belvoir, VA United States
  Connect »

Megan Kirkwood

Virginia Oncology Associates
Hampton, VA United States
  Connect »

Boston Biomedical

Blue Ridge Cancer Care
Roanoke, VA United States
  Connect »

Ibrahim Abukenda

Virginia Mason
Seattle, WA United States
  Connect »

Kristen Rivera

Seattle Cancer Care Alliance
Seattle, WA United States
  Connect »

Megan Kirkwood

Northwest Cancer Specialists, P.C.
Vancouver, WA United States
  Connect »

Mafizul Hoque

Bankstown-Lidcombe Hospital
Bankstown, Australia
  Connect »

Lalith Ratnayake

St Vincent's Hospital
Darlinghurst, Australia
  Connect »

Nadia Ranieri

St Vincent's hospital Melbourne
Fitzroy, Australia
  Connect »

Suzzanna Fettell

Port Macquaries Base Hospital
Port Macquarie, Australia
  Connect »

Karen Simmons

Sunshine Coast Hospital and Health Service
Nambour, Australia
  Connect »

Jacob Darch

Gold Coast University Hosptial
Southport, Australia
  Connect »

Boston Biomedical

Flinders Medical Centre
Bedford Park, Australia
  Connect »

Elizabeth Egan

The Queen Elizabeth Hospital
Woodville, Australia
  Connect »

Amy Clark

Bendigo Hospital
Bendigo, Australia
  Connect »

Albert Goikhman

Peninsula & South Eastern Haematology and Oncology Group
Frankston, Australia
  Connect »

Donna Haberl

Austin Hospital
Heidelberg, Australia
  Connect »

Maria Hadfield

Western Health
Melbourne, Australia
  Connect »

Carole Mott

Goulburn Valley Health
Shepparton, Australia
  Connect »

Doreen Iwens

Imelda Ziekenhuis
Bonheiden, Belgium
  Connect »

Nel Bovin

AZ Turnhout - Campus Sint-Elisabeth
Turnhout, Belgium
  Connect »

Mia Persoons

H pital Erasme
Bruxelles, Belgium
  Connect »

Janique Dewelle

Grand H pital de Charleroi - Site Notre-Dame
Charleroi, Belgium
  Connect »

Linda Evrard

CHU de Li ge - Domaine Universitaire du Sart Tilman
Bruxelles, Belgium
  Connect »

Hilde Marsé

UZ Leuven - Campus Gasthuisberg
Leuven, Belgium
  Connect »

Deborah Van Massenhove

AZ Sint-Jan Brugge - Oostende - Campus Sint-Jan
Brugge, Belgium
  Connect »

Tania Maerten

AZ Sint-Lucas - Campus Sint-Lucas
Brugge, Belgium
  Connect »

Amy Ng

Tom Baker Cancer Centre
Calgary, AB Canada
  Connect »

Amy Henderson

The Ottawa Hospital Cancer Centre
Ottawa, ON Canada
  Connect »

Kate Besel

University of Toronto - Sunnybrook Health Sciences Centre
Toronto, ON Canada
  Connect »

Amy Skitch

Saint Michael's Hospital Li Ka Shing Knowledge Institute
Toronto, ON Canada
  Connect »

Boston Biomedical

Beijing Cancer Hospital
Beijing, China
  Connect »

Boston Biomedical

Henan Cancer Hospital
Henan, China
  Connect »

Boston Biomedical

Jiangsu Province Hospital
Jiangsu, China
  Connect »

Petra Sevelova

Masarykuv onkologicky ustav
Brno, Czechia
  Connect »

Katja Richter

Leopoldina Krankenhaus Med. Klinik 2
Schweinfurt, Germany
  Connect »

Statesnne Kroening

Schwerpunkpraxis f r H matologie und Onkologie
Magdeburg, Germany
  Connect »

Evelyn Franke

Universit tsklinikum Carl Gustav Carus Dresden
Dresden, Germany
  Connect »

Anja Müller

Vivantes Klinikum Am Urban
Berlin, Germany
  Connect »

Sabine Krause

Charite - Campus Benjamin Franklin (Cbf)
Berlin, Germany
  Connect »

Antje Kallel

DRK Kliniken Berlin Koepenick
Berlin, Germany
  Connect »

Swetlana Wahnke

MVZ Onkologischer Schwerpunkt am Oskar-Helene-Heim
Berlin, Germany
  Connect »

Detlef-Andreas Fabian

Facharztzentrum Eppendorf
Hamburg, Germany
  Connect »

Mandy Wong

Pamela Youde Nethersole Eastern Hospital
Hong Kong, Hong Kong
  Connect »

Sandy Cheung

Queen Mary Hospital
Hong Kong, Hong Kong
  Connect »

Rossana Berardi

AOU Ospedali Riuniti Umberto I - GM.Lanc
Torrette di Ancona, Italy
  Connect »

Davide Pastorelli

Ospedale Santa Maria del Prato
Feltre, Italy
  Connect »

Luca Frassineti

Irccs Irst
Meldola, Italy
  Connect »

Stefano Tamberi

AUSL della Romagna, Osp. degli Infermi
Faenza, Italy
  Connect »

Andrea Ardizzoni

Policlinico S.Orsola Malpighi, AOU di Bologna
Bologna, Italy
  Connect »

Gianluca Tomasello

PO di Cremona, ASST di Cremona
Cremona, Italy
  Connect »

Alberto Sobrero

AO S. Martino, IRCCS, IST
Genova, Italy
  Connect »

Maria Giulia Zampino

Ieo, Irccs
Milano, Italy
  Connect »

Gabriele Luppi

AOU Policlinico di Modena
Modena, Italy
  Connect »

Fortunato Ciardiello

Universit degli studi della Campania "L.Vanvitelli"
Napoli, Italy
  Connect »

Luigi Cavanna

Ospedale Guglielmo da Saliceto, AUSL Piacenza
Piacenza, Italy
  Connect »

Boston Biomedical

Aichi Cancer Center Hospital
Nagoya, Japan
  Connect »

Boston Biomedical

National Cancer Center Hospital East
Kashiwa, Japan
  Connect »

Boston Biomedical

National Hospital Organization Shikoku Cancer Center
Matsunami, Japan
  Connect »

Boston Biomedical

Hokkaido University Hospital
Sapporo, Japan
  Connect »

Boston Biomedical

Kobe City Medical Center General Hospital
Kobe, Japan
  Connect »

Boston Biomedical

ST. Marianna University School of Medicine
Kawasaki, Japan
  Connect »

Boston Biomedical

Osaka University Hospital
Suita, Japan
  Connect »

Boston Biomedical

Osaka Medical College Hospital
Takatsuki, Japan
  Connect »

Boston Biomedical

Saitama Cancer Center
Kita-Adachi, Japan
  Connect »

Boston Biomedical

Shizuoka Cancer Center
Sunto, Japan
  Connect »

Boston Biomedical

Medical Hospital, Tokyo Medical and Dental University
Bunkyo-ku, Japan
  Connect »

Boston Biomedical

National Cancer Center Hospital
Chuo-ku, Japan
  Connect »

Boston Biomedical

The cancer insitute hospital of JFCR (Japanese Foundation For Cancer Research)
Koto-ku, Japan
  Connect »

Boston Biomedical

National Kyushu Cancer Center
Fukuoka, Japan
  Connect »

Boston Biomedical

Osaka Medical Center for Cancer and Cardiovascular Diseases
Osaka, Japan
  Connect »

Boston Biomedical

National Hospital Organization Osaka National Hospital
Osaka, Japan
  Connect »

Jyoti Pooja

Montefiore Medical Center
Bronx, NY United States
  Connect »

Rossana Berardi

AOU Ospedali Riuniti Umberto I - GM.Lanc
Torrette Di Ancona, Italy
  Connect »

Susan Poechhacker

Northern Cancer Institute
St Leonards, Australia
  Connect »

Boston Biomedical

Prince of Wales Hospital
Randwick, Australia
  Connect »

Zdenek Kral

Fakultni nemocnice Brno
Brno, Czechia
  Connect »

Lubos Petruzelka

Vseobecna fakultni nemocnice v Praze
Prague, Czechia
  Connect »

Veronique Guerin-Meyer

Centre Paul Papin
Angers, France
  Connect »

Jean-Philippe Metges

H pital Morvan - CHRU de Brest - canc rologie et d'h matolog
Brest, France
  Connect »

Denis Pezet

CHU Estaing
Clermont Ferrand, France
  Connect »

Francois Ghiringhelli

Centre de Lutte Contre le Cancer (CLCC)
Dijon, France
  Connect »

Yann Touchefeu

CHU de Nantes - Hopital Hotel Dieu
Nantes, France
  Connect »

Julien Taieb

H pital Europ en Georges Pompidou - Digestive Oncology
Paris, France
  Connect »

David Tougeron

Hospital of Poitiers
Poitiers, France
  Connect »

Marc Pracht

Centre Eugene Marquis
Rennes, France
  Connect »

Judith Raimbourg

Centre Rene Gauducheau
Saint-Herblain, France
  Connect »

Boston Biomedical

Gesundheitszentrum Wetterau
Bad Nauheim, Germany
  Connect »

Boston Biomedical

Charit Universit tsmedizin
Berlin, Germany
  Connect »

Boston Biomedical

Asklepios Klinik Altona
Hamburg, Germany
  Connect »

Boston Biomedical

Universit tsklinikum Marburg
Marburg, Germany
  Connect »

Boston Biomedical

Medizinische Universitaetsklin
Ulm, Germany
  Connect »

David Loven

Ha'Emek Medical Center
Afula, Israel
  Connect »

Noam Ansa

The Barzilai Medical Center - Oncology Institute
Ashkelon, Israel
  Connect »

Alexander Gluzman

Soroka University Medical Center
Be'er Sheva, Israel
  Connect »

Esther Tahover

Shaare Zedek Medical center
Jerusalem, Israel
  Connect »

Moshe Mishaeli

Meir Medical Center
Kefar Saba, Israel
  Connect »

Irit Ben-Aharon

Rabin MC - Oncology, Davidoff Center
Petah tikva, Israel
  Connect »

Jamal Zidan

Ziv Medical Center (The Rebecca Sieff Hospital)
Safed, Israel
  Connect »

Einat Shacham-Shmueli

The Chaim Sheba Medical Centre - Division of Oncology
Tel HaShomer, Israel
  Connect »

Ravit Jeva

Tel Aviv Sourasky Medical Center - Oncology
Tel-Aviv, Israel
  Connect »

Patrizia Racca

AOU Citt della Salute e della Scienza di Torino - Molinette
Torino, Italy
  Connect »

Jajesh Sharma

St. Mary's Hospital Center
Montréal, QC Canada
  Connect »

Julie Gosselin

Hopital Notre-Dame du CHUM
Montréal, QC Canada
  Connect »

Tereza Ptackova

FN Hradec Kralove
Hradec Králové, Czechia
  Connect »

Christophe Borg

Hospitalier Jean Minjoz
Besançon, France
  Connect »

Jerome Martin-Babau

H pital Priv des C tes d'Armor - Service oncologie
Plérin, France
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.