Last updated on February 2018

PET Imaging of Patients Using 124I-PU-AD

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Multiple Myeloma | Lymphoma | Solid Malignancy | Alzheimer's Disease
  • Age: Between 21 - 90 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Age between 21-90 years old.
  • Negative serum pregnancy test for females of childbearing age (11-50 years) and/or lack child-bearing potential.
  • No breast-feeding.
  • Patients with a diagnosis of cancer and/or Alzheimer's Disease, meeting trial eligibility criteria as specified below for either disease.
  • For cancer patients:
  • Patients with eligible histologic type of cancer. Eligible histologic types of cancer types include solid malignancy, myeloma, and lymphoma.
  • Cancer histology confirmed by MSKCC Department of Pathology.
  • Cancerous disease is radiologically-measurable or evaluable as defined by published tumor response criteria (including but not limited to RECIST 1.1).
  • For Alzheimer's Disease patients:
  • Established diagnosis of mild-moderate Alzheimer's disease based upon neurological and neuropsychological evaluation following the National Institute on Aging - Alzheimer's disease Association criteria that recently revisited the NINCDS-ADRDA criteria. Citation: PMID: 21514250
  • Documentation of diagnosis of mild-moderate Alzheimer's disease, as above, by board-certified neurologist (MSKCC or non-MSKCC)
  • Patient has an appointed health care proxy specifically designated for research consent and that this appointment is documented.
  • Patient has designated at-home caregiver(s) responsible for providing daily medications to the patient, who will document the patient's daily doses of SSKI oral medication, for 2 weeks as per study protocol.
  • For patients who have both cancer and Alzheimer's Disease, patients are considered eligible if they meet all eligibility requirements for either Alzheimer's Disease or cancer patients, as specified above.

Exclusion Criteria:

  • Previous allergic reaction to X-ray CT iodinated contrast medium.
  • Hypersensitivity to iodide products.
  • Known hyperthyroidism
  • Hepatic:
  • Bilirubin > 1.5 x institutional upper limit of normal (ULN)
  • AST/ALT >2.5 x ULN
  • Albumin < 2 g/dl
  • GGT > 2.5 x ULN IF Alkaline phosphatase > 2.5 x ULN
  • Renal: Creatinine >1.5 x ULN or creatinine clearance < 60 mL/min
  • Acute major illness (e.g., unstable cardiovascular condition.)
  • Patient inability to give consent personally or via appointed health care proxy

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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