Last updated on April 2016

Phase I Trial of BAY1251152 for Advanced Blood Cancers

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Hematologic Neoplasms
  • Age: Between 18 - 100 Years
  • Gender: Male or Female
  • Other:
    Male or female patients aged ≥18 years
    Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 and Life
    expectancy of at least 12 weeks
    Patients are able and willing to provide bone marrow biopsies/aspirates as requested
    by the protocol
    Patients with confirmed advanced hematological malignancies
    Negative serum pregnancy test
    Women and men of reproductive potential must agree to use highly effective
    contraception when sexually active.
    Ability to understand and the willingness to sign a written informed consent.
    Patients must have adequate coagulation (international normalized ratio (INR) or
    prothrombin time (PT), partial thromboplastin time (PTT) ≤1.5 times ULN)
    Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase
    (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN

You may not be eligible for this study if the following are true:

  • Presence of active/uncontrolled central nervous system involvement
    History of clinically significant cardiac disease; uncontrolled hypertension
    Left ventricular ejection fraction (LVEF) < 45%
    Allogeneic stem cell transplant within 100 days before first dose of study drug
    Known history of human immunodeficiency virus (HIV) infection
    Chronic or active hepatitis B or C, requiring antiviral therapy
    Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is
    distinct in primary site or histology from the cancer evaluated in this study
    Serious, uncontrolled infection
    Unresolved chronic toxicity > grade 1 from prior therapy
    Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of
    tudy treatment and for the duration of the study

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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