Last updated on September 2018

First-in-Human Safety and Tolerability Study of MTL-CEBPA in Patients With Advanced Liver Cancer


Brief description of study

This is a First in Human study of a new single agent (MTL-CEBPA) in patients with advanced cancer of the liver. The study is in two parts: dose escalation followed by a dose expansion; both parts of the study will recruit advanced hepatocellular carcinoma patients with cirrhosis. All participants will be refractory to or ineligible for loco-regional therapy including surgery, radiofrequency tumour ablation, transarterial chemoembolisation or sorafenib.

MTL-CEBPA consists of a double stranded RNA formulated into a SMARTICLES liposomal nanoparticle and is designed to activate the CEBPA gene.

Clinical Study Identifier: NCT02716012

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Recruitment Status: Open


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