Last updated on March 2019

A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenocarcinoma


Brief description of study

The purpose of this study is to compare the efficacy and safety of PEGylated Recombinant Human Hyaluronidase (PEGPH20) combined with nab-paclitaxel plus gemcitabine (PAG treatment), compared with placebo combined with nab-paclitaxel plus gemcitabine (AG treatment), in participants with hyaluronan (HA)-high Stage IV previously untreated pancreatic ductal adenocarcinoma (PDA). Participants will be randomized in a 2:1 ratio to PAG or AG treatment.

Clinical Study Identifier: NCT02715804

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University of South Alabama
Mobile, AL United States

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Banner MD Anderson Cancer Center
Gilbert, AZ United States

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HonorHealth Research Institute
Scottsdale, AZ United States

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Highlands Oncology Group
Fayetteville, AR United States

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St. Jude Hospital Yorba DBA Linda St. Joseph Heritage Health
Fullerton, CA United States

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Scripps Clinical Research Services
La Jolla, CA United States

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Long Beach Memorial Medical Center
Long Beach, CA United States

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David Geffen School of Medicine (DGSOM) at UCLA
Los Angeles, CA United States

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Samuel Oschin Comprehensive Cancer Institute
Los Angeles, CA United States

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Chao Family Comprehensive Cancer Center
Orange, CA United States

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St. Joseph Hospital
Orange, CA United States

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Desert Hematology Oncology Medical Group, Inc.
Rancho Mirage, CA United States

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Cancer Care Associates Medical Group, Inc.
Redondo Beach, CA United States

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Pacific Hematology Oncology Associates
San Francisco, CA United States

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UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, CA United States

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St Joseph Heritage Healthcare
Santa Rosa, CA United States

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Innovative Clinical Research Institution
Whittier, CA United States

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Kaiser Permanente Franklin Medical Offices - Denver
Denver, CO United States

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US Oncology - Rocky Mountain Cancer Centers - Midtown
Denver, CO United States

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St. Mary's Medical Center
Grand Junction, CO United States

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Yale Cancer Center
New Haven, CT United States

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Stamford Hospital - Carl and Dorothy Bennett Cancer Center
Stamford, CT United States

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MedStar Georgetown University Hospital
Washington, WA United States

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Memorial Healthcare System - Memorial Cancer Institute
Hollywood, FL United States

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21st Century Oncology
Jacksonville, FL United States

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MD Anderson Cancer Center Orlando
Orlando, FL United States

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Fort Wayne Medical Oncology/Hematology, INC.
Fort Wayne, IN United States

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The University Of Kansas Cancer Center
Kansas City, KS United States

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Ochsner Health Center
Baton Rouge, LA United States

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Ochsner Clinic CCOP
New Orleans, LA United States

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The Sidney Kimmel Comprehensive Cancer Center
Baltimore, MD United States

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Beth Israel Deaconess Medical Center
Boston, MA United States

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UMass Memorial Medical Center
Worcester, MA United States

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University of Michigan Medical Center
Ann Arbor, MI United States

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Karmanos Cancer Institute
Detroit, MI United States

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University of Minnesota Medical School
Minneapolis, MN United States

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Virginia Piper Cancer Institute
Minneapolis, MN United States

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Comprehensive Cancer Centers of Nevada
Las Vegas, NV United States

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Renown Regional Medical Center
Reno, NV United States

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Dartmouth Hitchcock Medical Center
Lebanon, NH United States

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Saint Joseph's Ambulatory Clinic
Clifton, NJ United States

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Jersey Shore University Medical Center
Neptune, NJ United States

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Valley Health System - The Valley Hospital (TVH)
Ridgewood, NJ United States

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Northwell Health/Monter Cancer Center
Lake Success, NY United States

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NYU Langone Medical Center - NYU Langone Arena Oncology
New Hyde Park, NY United States

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Columbia University Medical Center
New York, NY United States

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Mount Sinai School of Medicine - The Tisch Cancer Institute
New York, NY United States

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University of Rochester Medical Center
Rochester, NY United States

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Rex Cancer Center
Raleigh, NC United States

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Gabrail Cancer Center Research
Canton, OH United States

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The University of Oklahoma Health Sciences Center
Oklahoma City, OK United States

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Geisinger Health System
Danville, PA United States

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Penn State Milton S. Hershey Medical Center
Hershey, PA United States

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Allegheny General Hospital
Pittsburgh, PA United States

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Univ of Pittsburgh Cancer institute
Pittsburgh, PA United States

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Baylor College of Medicine - Baylor Clinic
Houston, TX United States

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Scott and White
Temple, TX United States

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University of Utah - Huntsman Cancer Institute
Salt Lake City, UT United States

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Inova Dwight and Martha Schar Cancer Institute
Fairfax, VA United States

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Fort Belvoir Community Hospital
Fort Belvoir, VA United States

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Virginia Cancer Institute
Mechanicsville, VA United States

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Swedish Cancer Institute/ Swedish Health Services
Seattle, WA United States

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University of Washington (UW) - Seattle Cancer Care Alliance
Seattle, WA United States

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Northwest Medical Specialties PLLC
Tacoma, WA United States

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University of Wisconsin Health - UW Carbone Cancer Center
Madison, WI United States

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Columbia St. Marys
Milwaukee, WI United States

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Medical College of Wisconsin
Milwaukee, WI United States

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Bankstown-Lidcombe Hospital
Bankstown, Australia

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Chris O'Brien Lifehouse
Camperdown, Australia

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St Vincent's Hospital
Darlinghurst, Australia

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Royal North Shore Hospital
St Leonards, Australia

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Royal Adelaide Hospital
Adelaide, Australia

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Flinders Medical Centre
Bedford, Australia

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Bendigo Health Care Group
Bendigo, Australia

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Monash Health
Bentleigh East, Australia

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Peninsula & South Eastern Haematology and Oncology Group
Frankston, Australia

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Imelda Ziekenhuis
Bonheiden, Belgium

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UZA
Edegem, Belgium

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H pital Erasme
Bruxelles, Belgium

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AZ Maria Middelares - Campus Maria Middelares
Gent, Belgium

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UZ Leuven - Campus Gasthuisberg
Leuven, Belgium

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Centre Hospitalier Universitaire (CHU) de Liege - Domaine Un
Liege, Belgium

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CENANTRON - Centro Avan ado de Tratamento Oncologico
Belo Horizonte, Brazil

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Centro Oncologico do Triangulo (COT)
Uberlandia, Brazil

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Hospital da Cidade de Passo Fundo
Passo Fundo, Brazil

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Hospital de Clinicas de Porto Alegre - UFRGS
Porto Alegre, Brazil

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Hospital S o Lucas da PUCRS
Porto Alegre, Brazil

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Occ -Oncologia Cl nica De Campinas
Campinas, Brazil

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Fm Abc/ Cepho
Santo Andre, Brazil

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Faculdade de Medicina da Universidade de Sao Paulo
Sao Paulo, Brazil

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Fundacao Pio XII Hospital De C ncer de Barretos
Barretos, Brazil

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Instituto COI
Rio de Janeiro, Brazil

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Instituto Nacional de C ncer - INCA
Rio de Janeiro, Brazil

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Royal Victoria Regional Health Centre
Barrie, ON Canada

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Princess Margaret Hospital
Toronto, ON Canada

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CHUM St-Luc Hospital
Montreal, QC Canada

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Jewish General Hospital
Montreal, QC Canada

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Klinicki bolnicki centar Zagreb
Zagreb, Croatia

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Opca bolnica Pula
Pula, Croatia

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Klinicki bolnicki centar Rijeka
Rijeka, Croatia

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Klinicki bolni ki centar Sestre milosrdnice
Zagreb, Croatia

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Masarykuv onkologicky ustav
Brno, Czechia

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FN Hradec Kralove
Hradec Kralove, Czechia

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Fakultni nemocnice Olomouc
Olomouc, Czechia

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Fakultni nemocnice v Motole
Praha 5, Czechia

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Regionshospitalet Herning (Herning Centralsygehus)
Herning, Denmark

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Odense Universitetshospital
Odense, Denmark

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Herlev Hospital
Herlev, Denmark

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East Tallinn Central Hospital Oncology Center
Tallinn, Estonia

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North Estonian Medical Centre Foundation Clinic of Oncology
Tallinn, Estonia

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Tartu University Hospital
Tartu, Estonia

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Centre Eugene Marquis
Rennes Cedex, France

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ICM Val d'Aurelle Saint Eloi - Departement Oncologie
Montpellier, France

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ICO - Site Ren Gauducheau
Saint Herblain, France

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CHU Estaing
Clermont-Ferrand, France

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Hopital Edouard Herriot
Lyon Cedex 03, France

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Institut De Cancerologie Gustave Roussy
Villejuif, France

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Institut de Canc rologie de l'Ouest - Site Paul Papin
Angers Cedex 02, France

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H pital Haut-Leveque
Bordeaux, France

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Centre Lyon Berard
Lyon Cedex, France

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Hopital Priv Jean Mermoz
Lyon, France

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Institut Mutualiste Montsouris
Paris, France

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Piti Salpetriere Hospital
Paris, France

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Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital
Toulouse, France

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H pital Beaujon
Clichy Cedex, France

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Universit tsklinikum Ulm
Ulm, Germany

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Universit tsklinikum Bonn
Bonn, Germany

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Uniklinik K ln-Klinik f r Gastroenterologie und Hepatologie am Abdominalzentrum
Koeln, Germany

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Universit tsklinik Carl-Gustav-Carus Dresden
Dresden, Germany

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Universit tsklinikum Leipzig A R
Leipzig, Germany

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Zentralklinik Bad Berka GmbH
Bad Berka, Germany

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Charit - Universit tsmedizin Berlin
Berlin, Germany

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Kliniken Essen-Mitte Evang. Huyssens-Stiftung
Essen, Germany

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Universit tsklinikum Halle-Universit tsklinik und Poliklinik
Halle, Germany

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Asklepios Klinik Altona
Hamburg, Germany

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Facharztzentrum Eppendorf
Hamburg, Germany

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Universit tskllinikum Heidelberg
Heidelberg, Germany

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B k s Megyei P ndy K lm n K rh z
Gyula, Hungary

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Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpo
Szeged, Hungary

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Abington Hospital
Abington, PA United States

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Ashford Cancer Centre Research
Kurralta Park, Australia

Trong Tuan Lê

Cliniques Universitaires Saint-Luc
Brussels, Belgium

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Pacific Central Coast Health Centers: San Luis Obispo Oncology and Hematology Health Center
San Luis Obispo, CA United States

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University of Louisville
Louisville, KY United States

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Funda o Amaral Cravalho / Hospital Amaral Carvalho
Jaú, Brazil

Petra Holeckova

Nemocnice Na Bulovce (Hospital Na Bulovce)
Prague, Czechia

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Hospitalier Jean Minjoz
Besançon cedex, France

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Henri Mondor - Albert Chevenier
Créteil, France

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Klinikum der Universit t M nchen - Campus Grosshadern
München, Germany

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P csi Tudom nyegyetem Klinikai K zpont
Pécs, Hungary

Recruitment Status: Closed


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