Last updated on September 2018

Effect of Diacerein vs Celecoxib on Symptoms and Structural Changes in Symptomatic Knee Osteoarthritis

Brief description of study

Osteoarthritis (OA) of the knee is the most frequent cause of knee pain after the age of 50 years. OA is a joint disease characterised by articular cartilage loss associated with structural changes in the cartilage and adjacent structures. The main symptoms are pain and functional disability. The goals of OA therapy are to decrease pain and maintain or improve joint function. There is evidence that diacerein has both a symptomatic and a structural effect on cartilage, and clinical studies suggest that diacerein therapy significantly decreases OA symptoms when compared to placebo. Diacerein has been shown to inhibit interleukine-1 (IL-1), and down-regulated IL-1 stimulated secretion of metalloproteinases and aggrecanases, and thereby prevent breakdown of cartilage by these enzymes. Diacerein has no effect on the synthesis of prostaglandins, and therefore no effect on the upper intestinal tract. The purpose of this phase III-IV international, multicentre, double-blind, non-inferiority, randomised, controlled study is to determine the efficacy and safety of diacerein vs. celecoxib on symptoms after 6 months of treatment, and on structural changes after 2 years of treatment in knee OA patients as assessed by magnetic resonance imaging (MRI).

Clinical Study Identifier: NCT02688400

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Burkhard F Leeb, MD

State Hospital Stockerau Karl Landsteiner Institute for Clinical Rheumatology
Stockerau, Austria

Pieter Reynders, MD

CHU Brugmann
Brussels, Belgium

Marc Leon, MD

Institut M dical Sp cialis - Centre DISCCA
Hornu, Belgium

Frank Raeman, MD

Reumatologie Medizorg Merksem
Merksem, Belgium

Jean-Pierre Brasseur, MD

CHU UCL Mont-Godinne
Yvoir, Belgium

Martin Cohen, MD

West Island Rheumatology Research Associates
Pointe-Claire, QC Canada

Pierre Arsenault, MD

Diex Recherche Serbrooke Inc.
Sherbrooke, QC Canada

Patrice Paiement, MSc

Orthopaedic Rehabilitation Center Zicksee Otto PohankaPlatz
Sankt Andrä am Zicksee, Austria

Serge Schreiber, MD

CHU Tivoli
La Louvière, Belgium

Jean-Pierre Raynauld, MD

Institut de recherche en rhumatologie de Montr al
Montréal, QC Canada

Murray Baron, MD

H pital G r ral Juif CIUSSS du Centre-Ouest-de-l' le-de-Montr al
Montréal, QC Canada

Patrice Paiement, MSc

PPS Medical Inc
Montréal, QC Canada

Julio Fernandes, MD

Hopital du Sacr Coeur de Montr al du CIUSS du Nord-de-l' le-de-Montr al
Montréal, QC Canada

André Fréchette, MD

Diex Recherche Qu bec Inc.
Québec City, QC Canada

Frédéric Morin, MD

Centre de recherche musculo-squelettique
Trois-Rivières, QC Canada

Louis Bessette, MD

G.R.M.O (Groupe de recherche en rhumatologie et maladies osseuses) Inc.
Québec, Canada

Recruitment Status: Closed

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