Last updated on February 2019

A Study of Atezolizumab in Combination With Carboplatin or Cisplatin + Pemetrexed Compared With Carboplatin or Cisplatin + Pemetrexed in Participants Who Are Chemotherapy-Naive and Have Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower 132)


Brief description of study

This is a randomized, Phase III, multicenter, open-label study designed to evaluate the safety and efficacy of atezolizumab in combination with cisplatin or carboplatin + pemetrexed compared with treatment with cisplatin or carboplatin + pemetrexed in participants who are chemotherapy-naive and have Stage IV non-squamous NSCLC. Eligible participants will be randomized by a 1:1 ratio into 2 groups: Arm A (Atezolizumab + Carboplatin or Cisplatin + Pemetrexed) and Arm B (Carboplatin or Cisplatin + Pemetrexed). The study will be conducted in two phases: Induction Phase and Maintenance Phase.

Clinical Study Identifier: NCT02657434

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Coast Hematology Oncology Associates
Long Beach, CA United States
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Los Angeles Hematology Oncology Medical Group
Los Angeles, CA United States
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St. Joseph Heritage Healthcare
Sebastopol, CA United States
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Stamford Hospital; BCC, MOHR
Stamford, CT United States
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Orlando Health Inc.
Orlando, FL United States
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Tallahassee Memorial Hospital
Tallahassee, FL United States
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Northside Hospital
Atlanta, GA United States
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Ingalls Memorial Hospital
Harvey, IL United States
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Illinois Cancer Care
Peoria, IL United States
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HealthCare Research Network II, LLC - PPDS
Tinley Park, IL United States
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Carle Cancer Center
Urbana, IL United States
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Fort Wayne Med Oncology & Hematology Inc
Fort Wayne, IN United States
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Goshen Health System
Goshen, IN United States
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University of Kentucky; Markey Cancer Center
Lexington, KY United States
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New England Cancer Specialists
Scarborough, ME United States
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Maryland Oncology Hematology Columbia - USOR
Columbia, MD United States
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University of Michigan
Ann Arbor, MI United States
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University of Minnesota.
Minneapolis, MN United States
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CHI Health St. Francis
Grand Island, NE United States
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Nebraska Methodist Hospital
Omaha, NE United States
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Cooper Health System; MD Anderson Cancer Center
Camden, NJ United States
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Trinitas Comprehensive Cancer Center
Elizabeth, NJ United States
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Swedish Cancer Institute
Cary, NC United States
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Providence Portland Medical Center
Portland, OR United States
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Hematology & Oncology Assoc; North Eastern Pennsylvania
Dunmore, PA United States
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Gettysburg Cancer Center
Gettysburg, PA United States
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Allegheny Cancer Center
Pittsburgh, PA United States
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Oncology Consultants PA
Houston, TX United States
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Virginia Cancer Specialists (Fairfax) - USOR
Fairfax, VA United States
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Peninsula Cancer Institute
Newport News, VA United States
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Blue Ridge Cancer Care
Roanoke, VA United States
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University of Washington
Seattle, WA United States
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St. Vincent Hospital
Green Bay, WI United States
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Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich
Buenos Aires, Argentina
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Fundacion Sanatorio Guemes
Buenos Aires, Argentina
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Fundacion Clinica Colombo
Cordoba, Argentina
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Centro de Investigacion; Clinica - Clinica Viedma S.A.
Viedma, Argentina
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St Vincent's Hospital Sydney
Darlinghurst, Australia
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Sydney Adventist Hospital; Clinical Trial Unit
Sydney, Australia
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St George Hospital; Medical Oncology
Sydney, Australia
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Cairns Base Hospital
Cairns, Australia
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Redcliffe Hospital
Redcliffe, Australia
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Mater Adult Hospital
South Brisbane, Australia
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Royal Hobart Hospital
Hobart, Australia
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Ballarat Health Services
Ballarat, Australia
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O . Gesundheits- und Spitals-AG/LKH Steyr
Steyr, Austria
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Klinikum Wels-Grieskirchen GmbH
Wels, Austria
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AZ Maria Middelares
Gent, Belgium
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Clinique Andr Renard; Pneumologie
Herstal, Belgium
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AZ Delta (Campus Wilgenstraat), Apotheek
Roeselare, Belgium
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Multiprofile Hospital for Active Treatment Serdika EOOD
Sofia, Bulgaria
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Multiprofile Hospital for Active Treatment Dji Med EOOD; Department of Medical Oncology
Village Branipole, Bulgaria
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Clinica Santa Maria
Santiago, Chile
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Health & Care SPA
Santiago, Chile
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Beijing Cancer Hospital
Beijing, China
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Hunan Cancer Hospital
Changsha City, China
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Changzhou First People's Hospital
Changzhou, China
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The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
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The First Affiliated Hospital of Medical School of Zhejiang University
Hangzhou City, China
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Zhejiang Cancer Hospital
Hangzhou, China
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Anhui Province Cancer Hospital
Hefei, China
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Shanghai Chest Hospital
Shanghai, China
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Fudan University Shanghai Cancer Center
Shanghai, China
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Zhongshan Hospital Fudan University
Shanghai, China
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Montefiore Medical Center
Bronx, NY United States
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Beijing Friendship Hospital Affiliated of Capital University of Medical Science
Beijing Shi, China
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Third Xiangya Hospital Centrel South University
Changsha, China
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Sir Run Run Shaw Hospital Zhejiang University
Hangzhou City, China
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First Hospital of China Medical University
Shenyang, China
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First Affliated Hospital of Anhui Medical University
Hefei, China
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Jilin Cancer Hospital
Changchun, China
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Fujian Medical University Union Hospital
Fujian, China
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Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University)
Nanjing City, China
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Peninsula and South Eastern Haematology and Oncology Group
Frankston, Australia
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Sociedad de Investigaciones Medicas Ltda (SIM)
Temuco, Chile
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Hospital Clinico Vina del Mar
Viña del Mar, Chile
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Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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